| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
In this study, we focused on function of the transmembrane protein teneurin-4 (Ten-4). In the Ten-4 deficient mice, hypomyelination of small-diameter axons was observed. The process formation of Ten-4 deficient oligodendrocytes was significantly reduced. Further, focal adhesion kinase (FAK) played a role downstream of Ten-4 in the process formation. This study will facilitate a better understanding of oligodendrocyte biology and be useful for application studies for the myelin-related diseases.
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