Clarification of the pathogenesis and development of treatments ofParkinson's disease using oxidative stress imaging

• Project/Area Number: 23790985
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: University of Fukui
• Principal Investigator: IKAWA Masamichi 福井大学, 医学部附属病院, 助教 (60444212)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経機能画像学 / パーキンソン病 / 酸化ストレス / 神経変性疾患 / PET / 脳機能イメージング / ミトコンドリア病

Research Abstract

The oxidative stress imaging using 62Cu-ATSM PET demonstrated that oxidative stress associates with striatal neurodegeneration in patients with Parkinson’ s disease. In addition, the FRAS4 system demonstrated that patients with mitochondrial diseases are always exposed to underlying oxidative stress.

Research Products

• [Journal Article] Hashimoto's encephalopathy with hippocampus involvement detected on continuous arterial spin labeling (2013)
  • Author(s): Ishitobi M, Yoneda M, Ikawa M, Matsunaga A, Ueno K, Kimura H, Wada Y.
  • Journal Title: Psychiatry Clin Neurosci Volume: 67 Pages: 128-129
  • Peer Reviewed
• [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration (2013)
  • Author(s): Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
  • Journal Title: Eur Neurol Volume: 69 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Hashimoto’s encephalopathy with hippocampus involvement detected on continuous arterial spin labeling (2013)
  • Author(s): Ishitobi M, Yoneda M, Ikawa M, Matsunaga A, Ueno K, Kimura H, Wada Y
  • Journal Title: Psychiatry Clin Neurosci Volume: 67 Issue: 2 Pages: 128-129
  • DOI: 10.1111/pcn.12019
  • Peer Reviewed
• [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration (2013)
  • Author(s): Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
  • Journal Title: Eur. Neurol Volume: 69 Issue: 1 Pages: 14-20
  • DOI: 10.1159/000342217
  • Peer Reviewed
• [Journal Article] PET - 62Cu-ATSM (2013)
  • Author(s): 井川 正道，岡沢 秀彦，米田誠
  • Journal Title: モダンフィジシャン Volume: 33 Pages: 577-579
• [Journal Article] Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA (2012)
  • Author(s): Ikawa M, Arakawa K, Hamano T, Nagata M, Nakamoto Y, Kuriyama M, Koga Y, Yoneda M
  • Journal Title: Eur Neurol. Volume: 67 Pages: 232-237
  • Peer Reviewed
• [Journal Article] Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings (2012)
  • Author(s): Kitai R, Hashimoto N, Yamate K, Ikawa M, Yoneda M, Nakajima T, Arishima H, Takeuchi H, Sato K, Kikuta KI
  • Journal Title: Brain Tumor Pathol Volume: 29 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Crossed cerebellar hyperperfusion after MELAS attack followed up by whole brain continuous arterial spin labeling perfusion imaging (2012)
  • Author(s): Tsujikawa T, Yamamoto T, Ikawa M, Yoneda M, Kimura H
  • Journal Title: Acta Radiol Volume: 53 Pages: 220-222
  • Peer Reviewed
• [Journal Article] Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrialDNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation (2012)
  • Author(s): Yoshii Y, Yoneda M, Ikawa M, Furukawa T, Kiyono Y, Mori T, Yoshii H, Oyama N, Okazawa H, Saga T, Fujibayashi Y.
  • Journal Title: Nucl Med Biol Volume: 39 Pages: 177-185
  • Peer Reviewed
• [Journal Article] In vivo functional brain imaging and a therapeutic trial of L-arginine in MELAS patients (2012)
  • Author(s): Yoneda M, Ikawa M, Arakawa K, Kudo T, Kimura H, Fujibayashi Y, Okazawa H
  • Journal Title: Biochim Biophys Acta - General Subjects. Volume: 1820 Pages: 615-618
  • Peer Reviewed
• [Journal Article] ミトコンドリア心筋症 (2012)
  • Author(s): 井川 正道, 米田 誠, 田中 雅嗣
  • Journal Title: 循環器内科 Volume: 72 Pages: 592-598
• [Journal Article] 最新のニューロイメージングと脳卒中治療への新たな展望造影剤を用いない灌流画像法 3D-ASL(3D-Arterial Spin Labeling)の基礎と応用 脳卒中、脳血管障害への臨床応用を中心に (2012)
  • Author(s): 木村 浩彦, 新井 良和, 菊田 健一郎, 井川 正道, 米田 誠
  • Journal Title: The Mt. Fuji Workshop on CVD. Volume: 30 Pages: 63-70
• [Journal Article] ミトコンドリア病 (2012)
  • Author(s): 井川 正道, 米田 誠
  • Journal Title: PHARM STAGE Volume: 12 Pages: 48-52
• [Journal Article] Evaluation of systemic redox states in patients carrying MELAS A3243G mutation in mitochondrial DNA. (2012)
  • Author(s): Masamichi Ikawa, Kenichiro Arakawa, Tadanori Hamano, Miwako Nagata, Yasunari Nakamoto, Masaru Kuriyama, Yasutoshi Koga, Makoto Yoneda.
  • Journal Title: European Neurology Volume: 67(4) Issue: 4 Pages: 232-7
  • DOI: 10.1159/000336568
  • Peer Reviewed
• [Journal Article] Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA (2012)
  • Author(s): Ikawa M, Arakawa K, Hamano T, Nagata M, Nakamoto Y, Kuriyama M, Koga Y, Yoneda M
  • Journal Title: Eur Neurol Volume: 67 Pages: 232-237
  • Peer Reviewed
• [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET (2011)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M
  • Journal Title: Nucl Med Biol Volume: 38 Pages: 945-951
  • Peer Reviewed
• [Journal Article] In vivo functional brain imaging and a therapeutic trial of 1-arginine in MELAS patients (2011)
  • Author(s): 米田誠、荒川健一郎、工藤崇, 他
  • Journal Title: Biochimica et Biophysica Acta (BBA) General Subjects Volume: (電子媒体) Issue: 5 Pages: 615-618
  • DOI: 10.1016/j.bbagen.2011.04.018
  • Peer Reviewed
• [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson’s disease using [62Cu]ATSM PET (2011)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M
  • Journal Title: Nucl Med Biol Volume: 38 Pages: 945-951
  • Peer Reviewed
• [Presentation] Detection of presymptomatically latent lesions developing into stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients (2013)
  • Author(s): Ikawa M, Kimura H, Muramatsu T, Matsunaga A, Tsujikawa T, Yamamoto T, Kosaka N, Kinoshita K, Yamamura O, Hamano T, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego (USA)
• [Presentation] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration. (2013)
  • Author(s): Kishitani T, Matsunaga A, Muramatsu T, Kame T, Ikawa M, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego (USA)
• [Presentation] Hashimoto's encephalopathy associated with anti-NAE autoantibodies; analysis of 101 patients (2013)
  • Author(s): Matsunaga A, Kishitani T, Muramatsu T, Ikawa M, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego (USA)
• [Presentation] MELAS 脳卒中様発作における MRI-ASL 法と MRSによる血流・代謝の経時的変化の検討 (2012)
  • Author(s): 井川 正道,辻川 哲也,村松 倫子,山元 龍哉,小坂 信之,木下 一之,中本 安成,木村 浩彦,米田 誠
  • Organizer: 第12回日本ミトコンドリア学会年会
  • Place of Presentation: つくば
• [Presentation] In vitro imaging of over-reduction state (oxidative stress) in cells with mitochondrial dysfunction using PET radiopharmaceutical Cu-ATSM (2012)
  • Author(s): Ikawa M, Yoshii Y, Nakamoto Y, Okazawa H, Fujibayashi Y, Yoneda M
  • Organizer: International Symposium of Asian Association of Aging Research 2012
  • Place of Presentation: 福岡
• [Presentation] Cu-ATSM PET による過還元状態(酸化ストレス)イメージングの基礎的研究 (2012)
  • Author(s): 井川 正道, 吉井 幸恵, 古川 高子, 清野泰, 森 哲也, 吉井 裕, 大山 伸幸, 岡沢秀彦, 佐賀 恒夫, 藤林 靖久, 米田 誠
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] MELAS 脳卒中様発作における MRI-ASL 法による発作前病変の血流評価 (2012)
  • Author(s): 村松 倫子, 井川 正道, 武田 朋子, 山元龍哉, 小坂 信之, 木下 一之, 木村 浩彦, 米田 誠
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] PET Imaging of Striatal Oxidative Stress in Patients with Parkinson's Disease Using 62Cu-ATSM (2012)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Nakamoto Y, Fujibayashi Y, Yoneda M
  • Organizer: The 64th Annual Meeting of American Academy of Neurology
  • Place of Presentation: New Orleans (USA)
• [Presentation] In Vitro and In Vivo Imaging of Over-reduction States (Oxidative Stress) in MELAS Using PET Radiopharmaceutical Cu-ATSM (2012)
  • Author(s): Yoneda M, Ikawa M, Yoshii Y, Nakamoto Y, Fujibayashi Y, Okazawa H
  • Organizer: The 64th Annual Meeting of American Academy of Neurology
  • Place of Presentation: New Orleans (USA)
• [Presentation] Hyperperfusion in "pre-stroke" lesions of MELAS detected by non-contrast media perfusion MR imaging. (2012)
  • Author(s): Muramatsu T, Ikawa M, Takeda T, Yamamoto T, Kosaka N, Kinoshita K, Nakamoto Y, Kimura H, Yoneda M
  • Organizer: 5th SFRR-ASIA 8th ASMRM 11th J-mit
  • Place of Presentation: 鹿児島
• [Presentation] In vitro imaging of over-reduction state (oxidative stress) in cells with mitochondrial dysfunction using PET radiopharmaceutical Cu-ATSM (2012)
  • Author(s): Ikawa M, Yoshii Y, Nakamoto Y, Okazawa H, Fujibayashi Y, Yoneda M
  • Organizer: International Symposium of Asian Association of Aging Research 2012
  • Place of Presentation: 福岡市
• [Presentation] Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less rho0 cells and the cybrids carrying MELAS mtDNA mutation (2011)
  • Author(s): Yoshii Y, Yoneda M, Ikawa M, Furukawa T, Kiyono Y, Mori T, Yoshii H, Oyama N, Okazawa H, Saga T, Fujibayashi Y
  • Organizer: World Molecular Imaging Congress 2011
  • Place of Presentation: San Diego (USA)
• [Presentation] Radiolabeled Cu-ATSM as a novel indicator of over-reduced states due to mitochondrial dysfunction: studies with mtDNA-lessρ0 cells and the cybrids carrying MELAS mtDNA mutation (2011)
  • Author(s): Yoneda M, Yoshii Y, Ikawa M, Takeda T, Furukawa T, Kiyono Y, Mori T, Yoshii H, Oyama N, Okazawa H, Fujibayashi Y.
  • Organizer: The 8th European Meeting on Mitochondrial Pathology
  • Place of Presentation: Zaragoza (Spain)
• [Presentation] Imaging of oxidative stress in patients with neurological disorders associated with mitochondrial dysfunction using 62Cu-ATSM PET (2011)
  • Author(s): Ikawa M, Okazawa H, Arakawa K, Takeda T, Kudo T, Kimura H, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Organizer: The 8th European Meeting on Mitochondrial Pathology
  • Place of Presentation: Zaragoza (Spain)
• [Presentation] A novel application of radiolabeled Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction: Studies with cybrids carrying mitochondrial DNA mutationfrom MELAS patients. Society of Nucelar Medicine (2011)
  • Author(s): Yoshii Y, Yoneda M, Ikawa M, Furukawa T, Kiyono Y, Mori T, Yoshii H, Oyama N, Okazawa H, Fujibayashi Y
  • Organizer: 58th Annual Meeting
  • Place of Presentation: San Antonio (USA)
• [Presentation] エネルギー代謝と酸化ストレスの機能イメージングによるミトコンドリア病の病態解明 (2011)
  • Author(s): 井川 正道,岡沢 秀彦,辻川 哲也,荒川 健一郎,土田 龍郎,河合 康幸,佐橋 功,工藤 崇,木村 浩彦,藤林 靖久,栗山 勝,米田 誠
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] Imaging of oxidative stress in patients with neurological disorders associated with mitochondrial dysfunction using 62Cu-ATSM PET (2011)
  • Author(s): Masamichi Ikawa, Hidehiko Okazawa, Kenichiro Arakawa, Tomoko Takeda, Takashi Kudo, Hirohiko Kimura, Masaru Kuriyama, Yasuhisa Fujibayashi, Makoto Yoneda
  • Organizer: The 8th European Meeting on Mitochondrial Pathology
  • Place of Presentation: サラゴサ，スペイン
• [Presentation] Radiolabeled Cu-ATSM as a novel indicator of over-reduced states due to mitochondrial dysfunction: studies with mtDNA-lessρ0 cells and the cybrids carrying MELAS mtDNA mutation (2011)
  • Author(s): Makoto Yoneda, Yukie Yoshii, Masamichi Ikawa, Tomoko Takeda, Takako Furukawa, Yasushi Kiyono, Tetsuya Mori, Hiroshi Yoshii, Nobuyuki Oyama, Hidehiko Okazawa, Yasuhisa Fujibayashi
  • Organizer: The 8th European Meeting on Mitochondrial Pathology
  • Place of Presentation: サラゴサ，スペイン
• [Presentation] PET Imaging of Striatal Oxidative Stress in Patients with Parkinson's Disease Using 62Cu-ATSM
  • Author(s): Ikawa M, Okazawa H, Kudo T, Nakamoto Y, Fujibayashi Y, Yoneda M
  • Organizer: The 64th Annual Meeting of American Academy of Neurology
  • Place of Presentation: New Orleans, USA
• [Presentation] In Vitro and In Vivo Imaging of Over-reduction States (Oxidative Stress) in MELAS Using PET Radiopharmaceutical Cu-ATSM
  • Author(s): Yoneda M, Ikawa M, Yoshii Y, Nakamoto Y, Fujibayashi Y, Okazawa H
  • Organizer: The 64th Annual Meeting of American Academy of Neurology
  • Place of Presentation: New Orleans, USA
• [Presentation] Detection of presymptomatically latent lesions developing into stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients
  • Author(s): Ikawa M, Kimura H, Muramatsu T, Matsunaga A, Tsujikawa T, Yamamoto T, Kosaka N, Kinoshita K, Yamamura O, Hamano T, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego, USA
• [Presentation] Hashimoto’s encephalopathy associated with anti-NAE autoantibodies; analysis of 101 patients
  • Author(s): Matsunaga A, Kishitani T, Muramatsu T, Ikawa M, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego, USA
• [Presentation] Hashimoto’s encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration
  • Author(s): Kishitani T, Matsunaga A, Muramatsu T, Kame T, Ikawa M, Nakamoto Y, Yoneda M
  • Organizer: The 65th Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego, USA
• [Presentation] MELAS脳卒中様発作における MRI-ASL法とMRSによる 血流・代謝の経時的変化の検討
  • Author(s): 井川 正道，辻川 哲也，村松 倫子，山元 龍哉， 小坂 信之，木下 一之，中本 安成，木村 浩彦，米田 誠
  • Organizer: J-mit2012
  • Place of Presentation: つくば市
• [Presentation] Cu-ATSM PETによる過還元状態（酸化ストレス）イメージングの基礎的研究
  • Author(s): 井川 正道，吉井 幸恵，古川 高子，清野 泰，森 哲也，吉井 裕，大山 伸幸，岡沢 秀彦，佐賀 恒夫，藤林 靖久，米田 誠
  • Organizer: 第53回神経学会学術集会
  • Place of Presentation: 東京
• [Book] Young woman with recurrent "stroke" attacks. Case Studies in Dementia: Common and Uncommon Presentations. (2011)
  • Author(s): Ikawa M, Yoneda M
  • Publisher: Cambridge University Press (London).