Biomarkers predicting therapeutic effects in patients with spinal and bulbar muscular atrophy (SBMA)

• Project/Area Number: 23790986
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: BANNO Haruhiko 名古屋大学, 高等研究院(医), 特任講師 (40594057)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 神経変性疾患 / 球脊髄性筋萎縮症 / 運動ニューロン疾患 / 臨床試験 / バイオマーカー / プロテオーム解析 / 分子標的治療 / プロテオミクス

Research Abstract

SBMA, also known as Kennedy’s disease, is an adult-onset, hereditarymotor neuron disease characterized by muscle atrophy, weakness and bulbar involvement. Given that SBMA is a slowly progressive disease, extremely long-term clinical trials are likely necessary to verify clinical benefits of disease-modifying therapies. Suitable surrogate endpoints, which reflect the pathogenesis and severity of SBMA, are thus substantial to assess the therapeutic efficacy in drug trials. To this end, appropriate biomarkers should be identified and validated in translational researches. In this research, we analyzed patients’ serum and urine using proteomics approach.

Research Products

• [Journal Article] Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy. (2012)
  • Author(s): Mano, T., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Hashizume, A., Tanaka, F., Sobue, G.
  • Journal Title: Muscle Nerve Volume: 46 Issue: 5 Pages: 692-697
  • DOI: 10.1002/mus.23413
  • Peer Reviewed
• [Journal Article] Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy. (2012)
  • Author(s): Hashizume, A., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Mano, T., Atsuta, N., Oe, H., Watanabe, H., Tanaka, F., Sobue, G.
  • Journal Title: Brain Volume: 35 Issue: 9 Pages: 2838-2848
  • DOI: 10.1093/brain/aws170
  • Peer Reviewed
• [Journal Article] Current status of treatment of spinal and bulbar muscular atrophy (2012)
  • Author(s): Tanaka F, Katsuno M, Banno H, Suzuki K, Adachi H, Sobue G
  • Journal Title: Neural Plast Volume: 2012 Pages: 369284-369284
  • DOI: 10.1155/2012/369284
  • Peer Reviewed
• [Journal Article] Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA) (2012)
  • Author(s): Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G
  • Journal Title: Prog Neurobiol Volume: 99 Issue: 3 Pages: 246-256
  • DOI: 10.1016/j.pneurobio.2012.05.007
  • Peer Reviewed
• [Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA). (2012)
  • Author(s): Banno, H., Katsuno, M., Suzuki, K., Tanaka, F., Sobue, G.
  • Journal Title: Cell Tissue Res Volume: 349 Issue: 1 Pages: 313-320
  • DOI: 10.1007/s00441-012-1377-9
  • Peer Reviewed
• [Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials. (2012)
  • Author(s): Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
  • Journal Title: Muscle Nerve Volume: 45 Issue: 2 Pages: 169-174
  • DOI: 10.1002/mus.22291
  • Peer Reviewed
• [Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy (2012)
  • Author(s): Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
  • Journal Title: Arch Neurol Volume: 69 Issue: 4 Pages: 436-440
  • DOI: 10.1001/archneurol.2011.2308
  • Peer Reviewed
• [Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group. (2012)
  • Author(s): Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
  • Journal Title: J Neurol. Volume: 259 Issue: 4 Pages: 712-719
  • DOI: 10.1007/s00415-011-6251-2
  • Peer Reviewed
• [Journal Article] Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy. (2012)
  • Author(s): Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
  • Journal Title: J Neurol. Volume: 259 Pages: 712-719
  • Peer Reviewed
• [Journal Article] Molecular pathophysiology and disease-modifying therapies for spinal and bulbar muscular atrophy. (2012)
  • Author(s): Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G.
  • Journal Title: Arch Neurol. Volume: 69 Pages: 436-440
  • Peer Reviewed
• [Journal Article] [Disease-modifying Therapy for Spinal and Bulbar Muscular Atrophy (SBMA)]. (2012)
  • Author(s): Suzuki K, Banno H, Katsuno M, Adachi H, Tanaka F, Sobue G.
  • Journal Title: Brain Nerve. Volume: 64 Pages: 237-244
  • NAID: 40019225495
  • Peer Reviewed
• [Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA). (2012)
  • Author(s): Banno H, Katsuno M, Suzuki K, Tanaka F, Sobue G.
  • Journal Title: Cell Tissue Res. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Dutasteride for spinal and bulbar muscular atrophy (2011)
  • Author(s): Banno H, Katsuno M, Suzuki K, Sobue G.
  • Journal Title: Lancet Neurol Volume: 10 Issue: 2 Pages: 113-5
  • DOI: 10.1016/s1474-4422(10)70324-0
  • Peer Reviewed
• [Journal Article] Dutasteride for spinal and bulbar muscular atrophy. (2011)
  • Author(s): Banno H, Katsuno M, Suzuki K, Sobue G.
  • Journal Title: Lancet Neurol. Volume: 10 Pages: 113-115
• [Presentation] 嚥下造影 3回法の信頼性・妥当性の検討 (2012)
  • Author(s): 坂野晴彦ら
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-24
• [Presentation] 球脊髄性筋萎縮症における嚥下造影の定性的・定量的解析(第二報) (2011)
  • Author(s): 坂野晴彦ら
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 臨床研究に関する倫理指針と臨床試験の実際 (2011)
  • Author(s): 坂野晴彦
  • Organizer: 第8回日本神経学会生涯教育セミナー「レクチャー」
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-17
• [Presentation] Effect of Leuprorelin in Patients with Spinal and Bulbar Muscular Atrophy (SBMA): A Multicenter, Randomized, Double-Blind (2011)
  • Author(s): Banno H., et al
  • Organizer: Placebo-Controlled Trial" 63rd Annual Meeting of the American Academy of Neurology
  • Place of Presentation: Hawaii, USA.
  • Year and Date: 2011-04-14
• [Presentation] 嚥下造影3回法の信頼性・妥当性の検討
  • Author(s): 坂野晴彦
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム（東京）
• [Book] "Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy (SBMA)." From Motor Neuron Diseases: Causes, Classification and Treatments (2012)
  • Author(s): Banno H, Katsuno M, Suzuki K, Tanaka F, Sobue G.
  • Publisher: Nova Science Publishers, Inc.
• [Book] 神経変性疾患の分子標的治療への問題点 SBMA を中心に- (2012)
  • Author(s): 坂野晴彦、勝野雅央、鈴木啓介、橋詰淳、祖父江元
  • Publisher: 北隆館、BIO Clinica
• [Book] 球脊髄性筋萎縮症、疾患別に診る嚥下障害 (2012)
  • Author(s): 坂野晴彦、勝野雅央、祖父江元
  • Publisher: 医歯薬出版
• [Book] “Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy (SBMA).” From Motor Neuron Diseases: Causes, Classification and Treatments. (2012)
  • Author(s): Banno H
  • Total Pages: 14
  • Publisher: Nova Science Publishers, Inc.
• [Book] BIO Clinica 神経変性疾患の分子標的治療への問題点―SBMAを中心に― (2012)
  • Author(s): 坂野晴彦
  • Total Pages: 5
  • Publisher: 北隆館
• [Book] 疾患別に診る嚥下障害 球脊髄性筋萎縮症 (2012)
  • Author(s): 坂野晴彦
  • Total Pages: 6
  • Publisher: 医歯薬出版
• [Book] Motor Neuron Diseases (2012)
  • Author(s): Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki Fumiaki Tanaka and Gen Sobue.
  • Publisher: Nova Science Publishers, Inc.
• [Book] 運動ニューロン疾患の病態に基づく画期的治療の開発 Annual Review 神経 (2011)
  • Author(s): 坂野晴彦、井口洋平、勝野雅央、鈴木啓介、祖父江元
  • Publisher: 中外医学社