Investigation into the pathogenesis of refractory neuropathies focusing on axon-myelin interaction.
Project/Area Number |
23790987
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Nagoya University |
Principal Investigator |
IIJIMA Masahiro 名古屋大学, 大学院・医学系研究科, COE 特任助教 (40437041)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 難治性ニューロパチー / 軸索-髄鞘間相互作用 / transient axoglial glycoprotein-1 (TAG-1) / 脱髄 / 軸索障害 / 脱髄(demyelination) / 軸索障害(axonal damage) / 軸索脆弱性 / 軸索-髄鞘相互作用 / TAG-1 / 実験的自己免疫性神経炎 / axon-glial interaction / ノックアウトマウス |
Research Abstract |
Axonal damage concomitant of inflammatory demyelination is one of the major factors for refractory or therapy-resistant peripheral neuropathies. In this study, we focused into transient axoglial glycoprotein-1 (TAG-1) which is related to axon-myelin interaction. We induced experimental autoimmune neuritis (EAN) on TAG-1 knockout (KO) mice and investigated phenotypes by clinicoelectrophysiological, and pathological analysis. As a result, the breakdown of the axon-myelin interaction could be associated to vulnerability of axonal function as well as refractory characteristics in inflammatory demyelinating neuropathies.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Autonomic manifestations in acute sensory ataxic neuropathy: A case report2013
Author(s)
Ohyama K, Koike H, Masuda M, Sone J, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Sobue G.
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Journal Title
Related Report
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[Journal Article] Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sjogren's syndrome-associated neuropathy.2012
Author(s)
Kawagashira Y, Koike H, Fujioka Y, Hashimoto R, Tomita M, Morozumi S, Iijima M, Katsuno M, Tanaka F, Sobue G
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Journal Title
J Neurol Sci.
Volume: 319
Pages: 139-46
Related Report
Peer Reviewed
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[Journal Article] The spectrum of clinicopathological features in pure autonomic neuropathy2012
Author(s)
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S, Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G.
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Journal Title
J Neurol.
Volume: 259
Pages: 2067-75
Related Report
Peer Reviewed
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[Journal Article] The spectrum of clinicopathological features in pure autonomic neuropathy.2012
Author(s)
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S,Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G.
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Journal Title
J Neurol
Volume: 259(10)
Pages: 2067-75
Related Report
Peer Reviewed
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[Journal Article] Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas2012
Author(s)
Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 83(2)
Pages: 152-8
Related Report
Peer Reviewed
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[Journal Article] Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation.2011
Author(s)
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 82(11)
Pages: 1287-90
Related Report
Peer Reviewed
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[Book] Annual Review神経2013巻2013
Author(s)
川頭 祐一, 飯島 正博, 小池 春樹, 祖父江 元
Total Pages
278
Publisher
各種疾患 末梢神経障害 抗MAG抗体陽性IgM-MGUSニューロパチーのリツキシマブによる新規治療の可能性
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