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Molecualr therapy and imaging for neurodegenerative disease with tissue specific targeting peptides

Research Project

Project/Area Number 23790988
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionShiga University of Medical Science

Principal Investigator

TERASHIMA Tomoya  滋賀医科大学, 医学部, 助教 (40378485)

Co-Investigator(Renkei-kenkyūsha) KOJIMA Hideto  滋賀医科大学, 医学部, 教授 (00225434)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords分子治療 / 遺伝子治療 / イメージング / 組織特異的ペプチド / 標的化 / 組織特異性 / 運動神経細胞 / 後根神経節細胞 / ターゲッティング / SOD1
Research Abstract

Engineering the new strategy of imaging or molecular therapy for spinal cord, we investigated to identify the specific peptides to bind with spinal cord. At last, we identified two kinds of peptides, which had high affinity with spinal cord. Next, we tried the examination for the imaging of spinal cord with using the peptides. Unfortunately, we couldn't success to establish the new imaging method with the peptides because the sensitivities had some problems. However, we succeeded the targeting to spinal cord with the peptides, which could effectively deliver the small oligonucleotides to spinal cord. This strategy has high potential to realize the new molecular therapy for non-curable neurological disease, which is expected to be arranged to more suitable condition for the neurodegenerative diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(55 results)

All 2014 2013 2012 2011 Other

All Journal Article Presentation Patent(Industrial Property Rights)

  • [Journal Article] Stem Cell Factor-Activated Bone Marrow Ameliorates Amyotrophic Lateral Sclerosis by Promoting Protective Microglial Migration2014

    • Author(s)
      Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H
    • Journal Title

      J. Neurosci. Res

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy2014

    • Author(s)
      Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H
    • Journal Title

      FEBS letters

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for neuropathic pain by silencing of TNF-αexpression with lentiviral vectors targeting the dorsal root ganglion in mice2014

    • Author(s)
      Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H
    • Journal Title

      PLoS One

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病性神経障害の細胞生物学 : 異常骨髄細胞の関わり2014

    • Author(s)
      寺島智也
    • Journal Title

      糖尿病合併症

      Volume: 28巻1号S2-3(in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stem Cell Factor-Activated Bone Marrow Ameliorates Amyotrophic Lateral Sclerosis by Promoting Protective Microglial Migration.2014

    • Author(s)
      Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H
    • Journal Title

      J. Neurosci. Res.

      Volume: 92

    • DOI

      10.1002/jnr.23368

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy2014

    • Author(s)
      Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H
    • Journal Title

      FEBS Letter

      Volume: 588 Pages: 1080-1086

    • DOI

      10.1016/j.febslet.2014.02.030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice2014

    • Author(s)
      Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0092073

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病性神経障害の細胞生物学:異常骨髄細胞の関わり.2014

    • Author(s)
      寺島智也
    • Journal Title

      糖尿病合併症

      Volume: 28

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 分子ZIPコード標識による超ウイルスベクターを用いたピンポイント遺伝子輸送2013

    • Author(s)
      寺島智也,小島秀人,大井二郎,川合寛道,前川聡
    • Journal Title

      滋賀医大誌

      Volume: 26(1)

    • Related Report
      2013 Final Research Report
  • [Journal Article] ファージディスプレイ法を用いた分子標的造影剤の開発 : マウス膵臓のβ細胞の造影2013

    • Author(s)
      椎野顯彦,小島秀人,小松直樹,小畑利之,寺島智也,前川聡,犬伏俊郎,柏木厚典
    • Journal Title

      滋賀医大誌

      Volume: 26(1)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝血管走行改変と遺伝子治療による全膵機能再生の試み2013

    • Author(s)
      藤野和典,小島秀人,松村一弘,樫美和子,寺島智也,小川暢弘
    • Journal Title

      滋賀医大誌

      Volume: 26(1)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 糖尿病合併症を誘導する異常骨髄幹細胞の同定と新規治療の開発2013

    • Author(s)
      小島秀人,樫美和子,寺島智也,前川聡,木村博
    • Journal Title

      滋賀医大誌

      Volume: 26(1)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013

    • Author(s)
      Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H
    • Journal Title

      Nat. Commun

      Volume: 4 Pages: 1526-1526

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013

    • Author(s)
      H Urabe, H Kojima, L Chan, T Terashima, N Ogawa, M Katagi, K Fujino, A Kumagai, H Kawai, A Asakawa, A Inui, H Yasuda, Y Eguchi, K Oka, H Maegawa, A kashiwagi, H Kimura
    • Journal Title

      Nat Commun

      Volume: 4 Pages: 1526-1526

    • DOI

      10.1038/ncomms2536

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 分子ZIP コード標識による超ウイルスベクターを用いたピンポイント遺伝子輸送2013

    • Author(s)
      寺島智也,小島秀人, 大井二郎, 川合寛道, 前川聡
    • Journal Title

      滋賀医大雑誌

      Volume: 26

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interleukin-7 induces recruitment of monocytes/macrophages to endothelium2012

    • Author(s)
      Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K
    • Journal Title

      Eur. Heart J

      Volume: 33(24) Pages: 3114-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion2012

    • Author(s)
      Terashima T, Kojima H, Chan L
    • Journal Title

      FASEB J

      Volume: 26 (1) Pages: 295-308

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve2012

    • Author(s)
      Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y
    • Journal Title

      PLoS One

      Volume: 7 (9)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve2012

    • Author(s)
      Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y.
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0044592

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.2012

    • Author(s)
      Terashima T, Kojima H, Chan L.
    • Journal Title

      The Federation of American Societies for Experimental Biology (FASEB) Journal

      Volume: 26 Pages: 295-308

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of diabetic neuropathy : bad to the bone2011

    • Author(s)
      Chan L, Terashima T, Urabe H, Lin F, Kojima H
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1240 Pages: 70-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Inactivation of TNF-αameliorates diabetic neuropathy in mice2011

    • Author(s)
      Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 301(5)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inactivation of TNF-α ameliorates diabetic neuropathy in mice.2011

    • Author(s)
      Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H.
    • Journal Title

      American Journal of Physiology. Endocrinology and Metabolism.

      Volume: 301

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of diabetic neuropathy: bad to the bone.2011

    • Author(s)
      Chan L, Terashima T, Urabe H, Lin F, Kojima H.
    • Journal Title

      Annals of the New York Academy of Sciences

      Volume: 1240 Pages: 70-76

    • DOI

      10.1111/j.1749-6632.2011.06309.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interleukin-7 induces recruitment of monocytes/macrophages to endothelium.2011

    • Author(s)
      Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K.
    • Journal Title

      European Heart Journal.

      Volume: In press

    • DOI

      10.1093/eurheartj/ehr245

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] TNFα発現抑制による脊髄後根神経細胞保護作用を介した神経因性疼痛への遺伝子治療2014

    • Author(s)
      小川暢弘、寺島智也、川合寛道、小島秀人、Kazuhiro Oka、Lawrence Chan、前川聡
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 標的化ナノダイヤモンドベクターの開発 : DRG神経細胞への遺伝子輸送ベクター2014

    • Author(s)
      中江由希、小島秀人、寺島智也、樫美和子、小川暢弘、岡野純子、Zhao Li、小松直樹、前川聡
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病性神経障害を誘導する異常な骨髄幹細胞の同定2014

    • Author(s)
      樫美和子、小島秀人、中江由希、寺島智也、岡野純子、宇田川潤、前川聡
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFα発現抑制による脊髄後根神経細胞保護作用を介した神経因性疼痛への遺伝子治療2014

    • Author(s)
      小川暢弘、寺島智也、川合寛道、小島秀人、Kazuhiro Oka、Lawrence Chan、前川 聡
    • Organizer
      日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 標的化ナノダイヤモンドベクターの開発:DRG神経細胞への遺伝子輸送ベクター2014

    • Author(s)
      中江由希、小島 秀人、寺島 智也、樫 美和子、小川 暢弘、岡野 純子、Zhao Li、小松 直樹、前川 聡
    • Organizer
      日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病性神経障害を誘導する異常な骨髄幹細胞の同定2014

    • Author(s)
      樫 美和子、小島 秀人、中江 由希、寺島 智也、岡野 純子、宇田川 潤、前川 聡
    • Organizer
      日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] SCF-activated bone marrow transplantation in ALS model mice2013

    • Author(s)
      Terashima T, Kojima H, Ogawa N, Yamakawa I, Urabe H, Kawai H, Maegawa H
    • Organizer
      The 24th Annual Meeting of the International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病性神経障害の細胞生物学 : 異常骨髄細胞の関わり2013

    • Author(s)
      寺島智也
    • Organizer
      日本糖尿病合併症学会総会シンポジウム
    • Related Report
      2013 Final Research Report
  • [Presentation] ALSモデルマウス脊髄組織におけるケモカイン発現と疾患関連性についての検討2013

    • Author(s)
      寺島智也、端真季子、小川暢弘、小島秀人、杉原芳子、山川勇、大井二郎、金一暁、川合寛道、前川聡
    • Organizer
      日本神経学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞標的化ナノダイヤモンドベクターの開発2013

    • Author(s)
      小島秀人、中江由希、早瀬史子、寺島智也、樫美和子、小松直樹
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病における骨髄幹細胞の分化異常と糖毒性メモリー2013

    • Author(s)
      樫美和子、寺島智也、小島秀人
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] ALSモデルマウス脊髄組織におけるケモカイン発現と疾患関連性についての検討.2013

    • Author(s)
      寺島智也、端真季子、小川暢弘、小島秀人、杉原芳子、山川 勇、大井二郎、金 一暁、川合寛道、前川 聡
    • Organizer
      日本神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病性神経障害の細胞生物学:異常骨髄細胞の関わり.2013

    • Author(s)
      寺島智也
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Annual Research Report
  • [Presentation] SCF-activated bone marrow transplantation in ALS model mice.2013

    • Author(s)
      Terashima T, Kojima H, Ogawa N, Yamakawa I, Urabe H, Kawai H, Maegawa H
    • Organizer
      The 24th Annual Meeting of the International Symposium on ALS/MND
    • Place of Presentation
      ミラノ、イタリア
    • Related Report
      2013 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおける骨髄由来細胞の治療有用性の検討2012

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川勇、早瀬史子、大井二郎、金一暁、川合寛道、前川聡
    • Organizer
      日本再生医療学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] ENGINIEERING OF GENE THERAPY FOR NEUROPATHIC PAIN BY SILENCING OF TNFαIN DRG FROM SPINAL NERVE TRANSECTION MODEL MOUSE2012

    • Author(s)
      Nobuhiro Ogawa, Tomoya Terashima, Kazuhiro Oka, Hideto Kojima, Fumiko Hayase, Jiro Oi, Isamu Yamakawa, Hyoh Kim, Lawrence Chan, Hiromichi Kawai, Hiroshi Maegawa
    • Organizer
      Japan Society of Gene Therapy
    • Related Report
      2013 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおけるSCF培養骨髄由来細胞の治療有用性2012

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川勇、早瀬史子、大井二郎、金一暁、川合寛道、前川聡
    • Organizer
      日本神経学会
    • Related Report
      2013 Final Research Report
  • [Presentation] カニクイザル脊髄後根神経節を用いた細胞特異的ターゲッティングの実現2012

    • Author(s)
      早瀬史子、寺島智也、中江由紀、大井二郎、小川暢弘、山川勇、金一暁、川合寛道、鳥居隆三、小島秀人、前川聡
    • Organizer
      日本神経学会
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFα発現抑制を介した神経因性疼痛に対する遺伝子治療法の開発2012

    • Author(s)
      小川暢弘、寺島智也、小島秀人、早瀬史子、金一暁、山川勇、川合寛道、前川聡、Kazuhiro Oka、Laurence Chan
    • Organizer
      日本神経学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症における骨髄由来細胞の関連性及び治療への有用性の検討2011

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川勇、片山由理、真田充、川合寛道、前川聡
    • Organizer
      日本神経学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症における骨髄由来細胞の関連性及び治療への有用性の検討2011

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川 勇、片山由理、真田 充、川合寛道、前川 聡
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおけるSCF培養骨髄由来細胞の治療有用性の検討.

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川 勇、早瀬史子、大井二郎、金 一暁、川合寛道、前川 聡.
    • Organizer
      第53回 日本神経学会学術大会
    • Place of Presentation
      東京 東京国際フォーラム
    • Related Report
      2012 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおける骨髄由来細胞の治療有用性の検討.

    • Author(s)
      寺島智也、小川暢弘、小島秀人、浦部博志、山川 勇、早瀬史子、大井二郎、金 一暁、川合寛道、前川 聡.
    • Organizer
      第11回 日本再生医療学会総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] カニクイザル脊髄後根神経節を用いた細胞特異的ターゲッティングの実現.

    • Author(s)
      早瀬史子、寺島智也、中江由紀、大井二郎、小川暢弘、山川 勇、金 一暁、川合寛道、小島秀人、前川 聡.
    • Organizer
      第53回 日本神経学会学術大会
    • Place of Presentation
      東京 東京国際フォーラム
    • Related Report
      2012 Research-status Report
  • [Presentation] TNFα発現抑制を介した神経因性疼痛に対する遺伝子治療法の開発.

    • Author(s)
      小川暢弘、寺島智也、小島秀人、早瀬史子、金 一暁、山川 勇、川合寛道、前川 聡、Kazuhiro Oka、Laurence Chan.
    • Organizer
      第53回 日本神経学会学術大会
    • Place of Presentation
      東京 東京国際フォーラム
    • Related Report
      2012 Research-status Report
  • [Presentation] ENGINIEERING OF GENE THERAPY FOR NEUROPATHIC PAIN BY SILENCING OF TNFα IN DRG FROM SPINAL NERVE TRANSECTION MODEL MOUSE.

    • Author(s)
      Nobuhiro Ogawa, Tomoya Terashima, Kazuhiro Oka, Hideto Kojima, Fumiko Hayase, Jiro Oi, Isamu Yamakawa, Hyoh Kim, Lawrence Chan, Hiromichi Kawai, Hiroshi Maegawa.
    • Organizer
      The 18th Annual Meeting of Japan Society of Gene Therapy.
    • Place of Presentation
      熊本 ホテル熊本テルサ
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞標的化ナノダイヤモンドベクターの開発.

    • Author(s)
      小島秀人、中江由希、早瀬史子、寺島智也、樫 美和子、小松直樹.
    • Organizer
      第12回 日本再生医療学会総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 糖尿病における骨髄幹細胞の分化異常と糖毒性メモリー.

    • Author(s)
      樫美和子、寺島智也、小島秀人.
    • Organizer
      第12回 日本再生医療学会総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 脊髄組織標的化ペプチド及びその利用2014

    • Inventor(s)
      寺島智也、前川 聡、小島秀人
    • Industrial Property Rights Holder
      国立大学法人滋賀医科大学
    • Industrial Property Number
      2014-082766
    • Filing Date
      2014-04-14
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 脊髄組織標的化ペプチド及びその利用2014

    • Inventor(s)
      寺島智也、前川 聡、小島秀人
    • Industrial Property Rights Holder
      国立大学法人滋賀医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-082766
    • Filing Date
      2014-04-14
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-04   Modified: 2019-07-29  

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