| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
The purpose of this study was to purify two glycoproteins, which is altered in Alzheimer's disease (AD) serum, analyze the region changed in AD, and then establish the measuring system. However, we had the problems during the steps of purify them, for example another sugar chains contaminated in the target glycoproteins. Although we cannot progress analysis, we finally decided the most suitable way to purify the proteins and are now advancing as the first planning. And we found the both content and the activity of serum sialyltransferase (STase) which attach the sialic acid to the transferrin are lower in Alzheimer's serum. This indicates one of the causes about altered sialic acid in AD.
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