A novel regeneration therapyof the chronic stage cerebral ischemia with porous gelatin scaffold

• Project/Area Number: 23790991
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Okayama University
• Principal Investigator: DEGUCHI Kentaro 岡山大学, 岡山大学病院, 助教 (80467753)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 慢性期脳梗塞 / 再生治療 / 軸索伸長関連因子 / ゼラチン多孔体 / 軸索伸長阻害因子 / 軸索伸長促進因子 / 脳梗塞 / 血管新生 / ペリサイト

Research Abstract

Changes in expression of neurorepair and neuroregenerative factors, which were important for the regeneration therapy of the chronic stage cerebral ischemia, were examined after transient rat cerebral ischemia. Immunohistochemistry and western blot analyses indicated that axonal growth inhibiting protein expression of neurocan, Sema3A, Nogo-R, and promoting protein expression of deleted in colorectal cancer was increased with edaravone, which was one of the free radical scavenger. The present study demonstrates that these protein factors ameliorated such damage inbrain repair after ischemia.

Research Products

• [Journal Article] A novel useful tool of computerized touch panel-type screening test for evaluating cognitive function of chronic ischemic stroke patients (2013)
  • Author(s): Deguchi K, Kono S, Deguchi S, Morimoto N, Kurata T, Ikeda Y, Abe K
  • Journal Title: J Stroke Cerebrovasc Dis
  • Peer Reviewed
• [Journal Article] Modifying neurorepair and neuroregenerative factors with tpa and edaravone after transient middle cerebral artery occlusion in rat brain (2012)
  • Author(s): Deguchi K, Miyazaki K, Abe K. et al
  • Journal Title: Brain Res Volume: Vol.1436 Pages: 168-177
  • Peer Reviewed
• [Journal Article] Spreading brain lesions in a familial creutzfeldt-jakob disease with v180i mutation over 4 years (2012)
  • Author(s): Deguchi K, Takamiya M, Deguchi S, Morimoto N, Kurata T, Ikeda Y, Abe K
  • Journal Title: BMC Neurol Volume: 12 Issue: 1 Pages: 144-144
  • DOI: 10.1186/1471-2377-12-144
  • Peer Reviewed
• [Journal Article] Modifying neurorepair and neuroregenerative factors with tpa and edaravone after transient middle cerebral artery occlusion in rat brain. (2012)
  • Author(s): Deguchi K, Miyazaki K, Tian F, Liu N, Liu W, Kawai H, Omote Y, Kono S, Yunoki T, Deguchi S, Abe K.
  • Journal Title: Brain Research Volume: 1436 Pages: 168-177
  • DOI: 10.1016/j.brainres.2011.12.016
  • Peer Reviewed
• [Presentation] ラット脳梗塞のtPAならびにedaravone投与におけるpericyteの関与 (2013)
  • Author(s): 出口健太郎 表芳夫 河野祥一郎 柚木太淳 劉檸 劉文涛 翟蘊 山下徹 阿部康二
  • Organizer: 第38回日本脳卒中学会総会
  • Place of Presentation: 東京
• [Presentation] タッチパネル式コンピューターを活用した脳梗塞既往患者の認知機能と画像所見の関連 (2012)
  • Author(s): 出口健太郎
  • Organizer: 第21回日本脳ドック学会総会
  • Place of Presentation: 広島
  • Year and Date: 2012-06-15
• [Presentation] ラット脳梗塞のedaravone投与による神経再生因子の発現増強効果 (2012)
  • Author(s): 出口健太郎
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-26
• [Presentation] ラット脳梗塞のedaravone投与による軸索伸長関連因子の発現増強効果 (2012)
  • Author(s): 出口健太郎 表芳夫 河野祥一郎 柚木太淳 劉檸 劉文涛 山下徹 阿部康二
  • Organizer: 第24回日本脳循環代謝学会
  • Place of Presentation: 広島
• [Presentation] ラット脳梗塞のtPAならびにedaravone投与における軸索伸長関連因子の発現 (2012)
  • Author(s): 出口健太郎 表芳夫 河野祥一郎 柚木太淳 河相裕美 田豊豊 劉檸 劉文涛 出口章子 阿部康二
  • Organizer: 第37回脳卒中学会総会
  • Place of Presentation: 福岡
• [Remarks]
  • URL: http://www.okayama-u.ac.jp/user/med/shinkeinaika/