| Project/Area Number |
23790996
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUSE Dai 九州大学, 医学研究院, 助教 (70596395)
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| Research Collaborator |
OGATA Hidenori 九州大学, 医学系学府, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細胞移植治療 / 間葉系細胞 / シュワン細胞 / 中枢性脱髄疾患 / 再生医療 / 中枢神経再生 / 神経再生 / 中枢神経 / 脱髄 |
|---|
| Research Abstract |
At first, we developed chronic experimental autoimmune encephalomyelitis (EAE) model rat from DA rats. We also induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of DA rats by adding several trophic factors. After developing EAE, BM-SCs, MSCs, or PBS (vehicle) were injected intrathecally. In BM-SC-transplanted group, clinical score and body weight recovered compared with the other 2 groups. Although the expression of PSA-NCAM was decreased in BM-SCs, the engraftment of these cells was successful. This treatment can be a breakthrough therapyfor central nervous system demyelinating disorder such as multiple sclerosis.
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