Treatment for central nervous system demyelinating disorder using mesenchymal cell-derived Schwann cells
Project/Area Number |
23790996
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Kyushu University |
Principal Investigator |
MATSUSE Dai 九州大学, 医学研究院, 助教 (70596395)
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Research Collaborator |
OGATA Hidenori 九州大学, 医学系学府, 大学院生
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 細胞移植治療 / 間葉系細胞 / シュワン細胞 / 中枢性脱髄疾患 / 再生医療 / 中枢神経再生 / 神経再生 / 中枢神経 / 脱髄 |
Research Abstract |
At first, we developed chronic experimental autoimmune encephalomyelitis (EAE) model rat from DA rats. We also induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of DA rats by adding several trophic factors. After developing EAE, BM-SCs, MSCs, or PBS (vehicle) were injected intrathecally. In BM-SC-transplanted group, clinical score and body weight recovered compared with the other 2 groups. Although the expression of PSA-NCAM was decreased in BM-SCs, the engraftment of these cells was successful. This treatment can be a breakthrough therapyfor central nervous system demyelinating disorder such as multiple sclerosis.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
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Journal Title
J Clin Invest
Volume: 123(1)
Issue: 1
Pages: 272-284
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: 22(9)
Issue: 9
Pages: 1613-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Multiliineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fijiyoshi Y, Dezawa M
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Journal Title
Proc.Natl.Acad.Sci.U.S.A.
Volume: 108(24)
Issue: 24
Pages: 9875-9880
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-neurofascin antibody in patients with combined central and peripheral demyelination
Author(s)
Kawamura N, Yamasaki R, Yonekawa T, Matsushita T, Kusunoki S, Nagayama S, Fukuda Y, Ogata H, Matsuse D, Murai H, Kira J.
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Journal Title
Neurology
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection.
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Jorge J. Riera, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: (in press)
Related Report
Peer Reviewed
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[Book] 多発性硬化
Author(s)
松瀬大, 吉良潤一
Publisher
南山堂(印刷中)
Related Report