A pathological study of impaired cytoplasmic-nuclear transport impairment infamilial ALS patients harboring FUS mutatio
| Project/Area Number |
23790997
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 筋萎縮性側索硬化症 / FUS / 神経化学 / サイトカイン / ケモカイン / 神経病理学 |
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| Research Abstract |
We first showed that in the spinal motor neurons of familial and sporadic amyotrophic lateral sclerosis (ALS) patients, cytoplasmic-nuclear transport of transcriptional mediators were impaired. We analyzed on this issue using SOD1-trangenic mouse, and revealed that these pathological findings were detectable prior to motor neuron degeneration
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation2012
Author(s)
Saiga T, Tateishi T, Torii T, Kawamura N, Nagara Y, Shigeto H, Hashiguchi A, Takashima H, Honda H, Ohyagi Y, Kira J.
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Journal Title
Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation
Volume: 83
Issue: 7
Pages: 763-764
DOI
Related Report
Peer Reviewed
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