Role of cellular senescence factor Ecrg4-investigating its expression and identifying its receptor which may be a therapeutic target in Alzheimer's Disease

• Project/Area Number: 23791001
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: KUJURO Yuki 慶應義塾大学, 医学部, 助教 (60398625)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 細胞老化 / アルツハイマー病 / 受容体 / 分泌因子 / 認知症 / Ecrg4

Research Abstract

In the brains of ApoE4 Alzheimer’s Disease transgenic mice, SA-β-gal activity and expression of Ecrg4 was elevated compared to non transgenic mice. Our data suggests that cellular senescence might be one of the causal mechanisms of Alzheimer’s Disease. By