Investigation of cellular toxicity induced by LIN28 in amyotrophic lateral sclerosis
| Project/Area Number |
23791002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋萎縮性側索硬化症 (ALS) / TDP-43 / 胚性幹細胞 (ES 細胞) / 運動神経細胞死 / 筋萎縮性側索硬化症 / ALS / 胚性幹細胞 / ES細胞 / マグネトフェクション / RNA編集 / LIN28 / ADAR2 / 胚性幹細胞 (ES細胞) / 運動神経細胞 |
|---|
| Research Abstract |
We established the procedures of transfection into human motor neurons derived from embryonic stem (ES) cells, of which magnetofection was proved most useful. Taking advantage of this procedure, 26k-Da C terminal isoform and mutant forms of TDP-43, that i
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways2012
Author(s)
Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y, Kawase T, Iwanami A, Mischel PS, Saya H, Yoshida K, Matsuzaki Y, Okano H
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Journal Title
PLoS One
Volume: 7(3)
Issue: 3
Pages: e33431-e33431
DOI
Related Report
Peer Reviewed
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