Autozygosity mapping in consanguineous families with Parkinson's disease
| Project/Area Number |
23791003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
LI Yuanzhe 順天堂大学, 医学研究科, 博士研究員 (40549292)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 家族性パーキンソン病 / オート接合性マッピング / 劣性遺伝子パーキンソン病 / パーキンソン病 / 血族婚 / 劣性遺伝性PD |
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| Research Abstract |
This study identified a candidate gene for Parkinson’s disease by autozygosity mapping and whole-exome sequencing in consanguineous families with Parkinson’s disease (FPD). Accordingly, I performed mutation analysis of the candidate gene on 500 patients with FPD. However, no mutations were detected. I still cannot conclude whether the gene is the gene responsible for FPD. Therefore, further investigations areneeded to identify the gene responsible for FPD.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis2012
Author(s)
Ogaki K, Li Y, Atsuta N, Tomiyama H, Funayama M, Watanabe H, Nakamura R, Yoshino H, Yato S, Tamura A, Naito Y, Taniguchi A, Fujita K, Izumi Y, Kaji R, Hattori N, Sobue G
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Journal Title
Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis
Volume: 33
Issue: 10
Pages: 2527.e11-2527.e16
DOI
Related Report
Peer Reviewed
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