| Project/Area Number |
23791007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
|
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KINO Yoshihiro 独立行政法人理化学研究所, 脳科学総合研究センター, 客員研究員 (80415140)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | 神経変性疾患 / ポリグルタミン / RNA結合タンパク質 / 凝集体 / リピート伸長疾患 |
|---|
| Research Abstract |
Polyglutamine diseases, including Huntington's disease, are genetic disorders caused by a repeat expansion of CAG repeat tracts in protein-coding regions. This study revealed aberrant RNA processing in polyglutamine diseases using cultured cells and disease model mice, suggesting the involvement of RNA-binding proteins in the disease pathogenesis. In addition, RNA-binding proteins have a potential regulatory role in the expression of the gene products of a polyglutamine disease.
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