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Examination of treatment of myasthenia gravis with antibodies against muscle-specific kinase using experimental animal model.

Research Project

Project/Area Number 23791009
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

MORI Shuuichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30508677)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経分子病態学 / 神経筋シナプス / 重症筋無力症 / MuSK
Research Abstract

This study examined the availability of a novel drug in the treatment of myasthenia gravis with antibodies against muscle-specific kinase (MuSK-MG) using experimental animal model. The results provided the evidence that only low-dose cholinesterase inhibitors should be used to avoid side effect, and that 3,4-diaminopyridine will be effective as a mainstay in the symptomatic therapy of MuSK-MG.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 7 results) Presentation (12 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis.2013

    • Author(s)
      Mori S, Shigemoto K.
    • Journal Title

      Autoimmun Rev

      Volume: (in press) Issue: 9 Pages: 912-7

    • DOI

      10.1016/j.autrev.2013.03.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経筋接合部の異常と筋萎縮2013

    • Author(s)
      森 秀一, 重本 和宏
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 696-703

    • Related Report
      2012 Final Research Report
  • [Journal Article] サルコペニア発症のメカニズム2013

    • Author(s)
      宮崎剛
    • Journal Title

      腎と骨代謝

      Volume: 26 Pages: 99-107

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 神経筋接合部の維持機構と筋萎縮2013

    • Author(s)
      森秀一
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 696-703

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 筋肉と神経-最新知見を踏まえて2013

    • Author(s)
      重本和宏
    • Journal Title

      Bone Joint Nerve

      Volume: 3 Pages: 27-31

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 筋肉の老化2013

    • Author(s)
      重本和宏
    • Journal Title

      Clinical Calcium

      Volume: 23 Pages: 23-28

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption.2012

    • Author(s)
      Miyazaki T, Iwasawa M
    • Journal Title

      J Biol Chem.

      Volume: 287(45) Issue: 45 Pages: 34808-23

    • DOI

      10.1074/jbc.m112.385369

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      森 秀一, 山田 茂, 秋好 沢諭, 福永 大地, 重本 和宏
    • Journal Title

      健康医科学

      Volume: 27 Pages: 148-56

    • Related Report
      2012 Final Research Report
  • [Journal Article] 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis2012

    • Author(s)
      Mori, S. , Kishi, M., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Konishi, T., Maruyama, N., and Shigemoto, K.
    • Journal Title

      Journal of neuroimmunology

      Volume: 245 Issue: 1-2 Pages: 75-78

    • DOI

      10.1016/j.jneuroim.2012.02.010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis2012

    • Author(s)
      Mori, S. , Yamada, S., Kubo, S. , Chen, J., Matsuda, S. , Shudou, M. , Maruyama, N., and Shigemoto, K.
    • Journal Title

      Journal of neuroimmunology

      Volume: 244 Issue: 1-2 Pages: 1-7

    • DOI

      10.1016/j.jneuroim.2011.12.005

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012

    • Author(s)
      Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Hotta H, Desaki J, Kishi M, Konishi T, Nishino Y, Miyazawa A, Maruyama N, Shigemoto K
    • Journal Title

      The American Journal of Pathology

      Volume: 180 Issue: 2 Pages: 617-28

    • DOI

      10.1016/j.ajpath.2011.10.031

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 老齢マウスの筋線維タイプ特異的な筋萎縮の病態解明2012

    • Author(s)
      福永大地
    • Journal Title

      基礎老化研究

      Volume: 36 (3) Pages: 47-49

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet2011

    • Author(s)
      Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Metabolism

      Volume: 60 Issue: 5 Pages: 617-28

    • DOI

      10.1016/j.metabol.2010.06.008

    • NAID

      40018948824

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport2011

    • Author(s)
      Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A.
    • Journal Title

      Journal of biochemistry

      Volume: 150 Issue: 6 Pages: 671-678

    • DOI

      10.1093/jb/mvr109

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 3,4-diaminopyridine to treatment of a MuSK antibody-induced mouse model of myasthenia gravis.2012

    • Author(s)
      Mori S.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経筋シナプスの維持メカニズムの解明とサルコペニア研究への展開2012

    • Author(s)
      森 秀一
    • Organizer
      日本体力医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗MuSK抗体陽性重症筋無力症の発症メカニズムに基づく治療薬の検討2012

    • Author(s)
      森 秀一.
    • Organizer
      日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Distinct mechanism between divalent and monovalent MuSK antibodies are involved with dysfunction of MuSK leading to myasthenia gravis.2011

    • Author(s)
      Mori S.
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      Washington, D.C. (USA)
    • Year and Date
      2011-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] MuSK とDok-7の相互作用は神経筋シナプスの維持に重要である2011

    • Author(s)
      森 秀一
    • Organizer
      日本体力医学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Distinct mechanism between divalent and monovalent MuSK antibodies are involved with dysfunction of MuSK leading to myasthenia gravis.2011

    • Author(s)
      Mori S.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis.2011

    • Author(s)
      Mori S
    • Organizer
      第34回日本神経科学会大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] MuSKとDok-7の相互作用は神経筋シナプスの維持に重要である.2011

    • Author(s)
      森秀一
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関
    • Related Report
      2011 Research-status Report
  • [Presentation] Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis.2011

    • Author(s)
      Mori S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Research-status Report
  • [Presentation] Effectiveness of 3,4-diaminopyridine to treatment of a MuSK antibody-induced mouse model of myasthenia gravis.

    • Author(s)
      Mori S
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経筋シナプスの維持メカニズムの解明とサルコペニア研究への展開

    • Author(s)
      森秀一
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗MuSK抗体陽性重症筋無力症の発症メカニズムに基づく治療薬の検討

    • Author(s)
      森秀一
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 運動神経細胞とサルコペニア2011

    • Author(s)
      重本和宏
    • Total Pages
      2
    • Publisher
      新興医学出版社
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.tmghig.jp/J_TMIG/j_research/DA33.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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