Role of hepatic amino acid metabolism on the development of metabolic syndrome
Project/Area Number |
23791011
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Tohoku University |
Principal Investigator |
UNO Kenji 東北大学, 病院, 助教 (50596632)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | アミノ酸代謝 / メタボリックシンドローム / 肥満 / mTOR |
Research Abstract |
Metabolism in different tissues/organs is regulated via both neuronal and humoral factors. We have previously demonstrated that neuronal networks, especially from the liver, play important roles in maintaining metabolic homeostasis among organs/tissues, including adipose tissue and pancreatic islets. Nutrient (carbohydrate, fat, and protein) overloads due to overeating affect these regulational systems, resulting in progression of metabolic disorders. In this study, we purpose to identify a new role of hepatic amino acid metabolismon the development of metabolic syndrome.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Chronic mild stress alters circadian expressions ofmolecular clock genes in the liver2012
Author(s)
Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 304(3)
Issue: 3
Pages: E301-E309
DOI
Related Report
Peer Reviewed
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[Journal Article] Importance of endothelial NF-κB signaling in vascular remodeling and aortic aneurysm formation2012
Author(s)
Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
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Journal Title
Cardiovascular Research
Volume: 97(1)
Issue: 1
Pages: 106-114
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012
Author(s)
Sohei Tsukita, Tetsuya Yamada, Kenji Uno, Kei Takahashi, Keizo Kaneko, Yasushi Ishigaki, Junta Imai, Yutaka Hasegawa, Shojiro Sawada, Hisamitsu Ishihara, Yoshitomo Oka, Hideki Katagiri
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Journal Title
Cell Metab
Volume: 16
Pages: 825-32
Related Report
Peer Reviewed
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[Journal Article] Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vasal signals2012
Author(s)
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H
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Journal Title
Eur Heart J
Volume: (In Press)
Issue: 10
Pages: 1279-1289
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012
Author(s)
Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H.
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Journal Title
Cell Metab
Volume: 16(6)
Issue: 6
Pages: 825-832
DOI
Related Report
Peer Reviewed
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[Journal Article] Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans.2012
Author(s)
Hasegawa Y, Saito T, Ogihara T, Ishigaki Y, Yamada T, Imai J, Uno K, Gao J, Kaneko K, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
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Journal Title
Circulation
Volume: 125
Pages: 1122-1133
Related Report
Peer Reviewed
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[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011
Author(s)
Junhong Gao, Yasushi Ishigaki, Tetsuya Yamada, Keiichi Kondo, Suguru Yamaguchi, Junta Imai, Kenji Uno, Yutaka Hasegawa, Shojiro Sawada, Hisamitsu Ishihara, Seiichi Oyadomari, Masataka Mori, Yoshitomo Oka, and Hideki Katagiri
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Journal Title
Circulation
Volume: 124
Pages: 830-9
Related Report
Peer Reviewed
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[Journal Article] Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals.2011
Author(s)
Kenji Uno, Tetsuya Yamada, Yasushi Ishigaki, Junta Imai, Yutaka Hasegawa, Junhong Gao, Keizo Kaneko, Kimihiko Matsusue, Tomomi Yamazaki, Yoshitomo Oka, and Hideki Katagiri.
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Journal Title
European Heart Journal
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses.2011
Author(s)
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H.
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Journal Title
Circulation
Volume: 124
Pages: 830-839
Related Report
Peer Reviewed
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