The elucidation of physiological functions of transcription factor FoxO1 in pancreatic alpha cell
Project/Area Number |
23791013
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
|
Research Institution | Gunma University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 糖尿病 / 膵臓 / α細胞 / グルカゴン / FoxO1 / FoxO1 |
Research Abstract |
To elucidate the physiological roles of FoxO1 in pancreatic alpha cell, we prepared and analyzed the character of alpha cell-specific constitutive active-FoxO1 knockin mice (alpha-FoxO1-KI). Alpha-FoxO1 KI mice showed significant increases in plasma glucagon and blood glucose levels under random fed condition. We conclude that FoxO1 promotes glucagon secretion from pancreatic alpha cell.
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Report
(3 results)
Research Products
(8 results)