| Project/Area Number |
23791014
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
|
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| Research Institution | Teikyo University (2012)
Gunma University (2011) |
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Principal Investigator |
|
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
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| Keywords | エネルギー / 糖質代謝異常 / pH / インスリン / プロトン / 糖代謝 / OGR1ファミリー / GPCR / INS-1細胞 |
|---|
| Research Abstract |
OGR1 family receptors response to extracellular pH and lysolipid, however its functions in insulin secretion are unknown. In this study, we investigated glucose tolerance and insulin sensitivity in OGR1-deficient mice. Moreover, islets isolated from OGR1-deficient mice and INS-1 cells were analyzed for the mechanisms of insulin secretion by acidification of extracellular pH. These results indicated that OGR1 responded to extracellular pH andregulated the glucose-stimulated insulin secretion in the pancreatic beta cells.
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