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In vivo imaging revealed molecular mechanisms of metabolic syndrome and novel biomarkers

Research Project

Project/Area Number 23791016
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

NAGASAKI Mika  東京大学, 医学部附属病院, 特任助教 (70456135)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords共焦点顕微鏡 / メタボリック症候群 / 免疫異常 / リモデ リング / 脂肪組織 / リモデリング / 血清脂質
Research Abstract

To elucidate the underlying mechanisms of metabolic diseases based on chronic inflammation, it is vital to examine the multi-cellular kinetics in living animals. Therefore, we developed in vivo imaging technique based on single- and multi-photon microscopy, and we assessed dynamic immune and inflammatory cellular interplay in diseased conditions. Using this technique, we visualized cell kinetics in metabolic organs including adipose tissue. We also developed FACS analysis methods of metabolic organs, and we identified a novel B cell subset that is abundant in adipose tissue. Adipose B cells also exhibited unique surface phenotypes, distinct from those of known regulatory B cell subsets. Our findings indicate that adipose B cells are a naturally occurring regulatory B cell subset that is essential for negative regulation of diet-induced adipose inflammation and maintenance of homeostasis within adipose tissue, and that B cell dysfunction pivotally contributes to the progression of infla … More mmatory and fibrotic processes.It is known that in obesity adipose tissue expands through both adipocyte hypertrophy and hyperplasia, and that inflammation is induced within visceral adipose tissue. The underlying mechanism that controls these dynamic changes is still not well understood, however. We found that autotaxin (ATX) is an adipose-derived, secreted enzyme that contributes to adipose expansion and inflammation. ATX+/- and adipocyte specific ATX knockout mice fed a high-fat diet exhibited smaller body weight gains than control micefed the same diet. Preadipocytes from ATX+/- mice showed less capacity to proliferate and differentiate into adipocytes than those from ATX+/+ mice. In addition, adipose inflammation was ameliorated by ATX haploinsufficiency. Despite its contribution to adipose obesity, ATX expression was downregulated in obese adipose tissue in mice. Similarly, serum ATX levels were reduced in obese human subjects and were independently correlated with obesity. Taken together, our results establish ATX as an adipose-derived, secreted enzyme that is downregulated in obesity but is centrally involved in mediating adipose obesity. Less

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (79 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (62 results) (of which Invited: 2 results) Book (9 results) Remarks (2 results)

  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.
    • Journal Title

      Blood

      Volume: 119(8)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adipose tissue remodeling associated with chronic inflammation and abnormal local immunity in obesity visualized by in vivo molecular imaging method2012

    • Author(s)
      Nishimura S, Nagasaki M, Sugita J
    • Journal Title

      Inflammation and Regeneration

      Volume: 32(4) Pages: 165-170

    • NAID

      130004943823

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adipose tissue remodeling associated with chronic inflammation and abnormal local immunity in obesity visualized by in vivo molecular imaging method.2012

    • Author(s)
      Nishimura S, Nagasaki M, Sugita J.
    • Journal Title

      Inflammation and Regeneration

      Volume: 32(4) Pages: 165-170

    • NAID

      130004943823

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivoimaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H
    • Journal Title

      Blood

      Volume: 119(8)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2011

    • Author(s)
      S.Nishimura
    • Journal Title

      Blood

      Volume: 119 Issue: 8 Pages: 128-131

    • DOI

      10.1182/blood-2011-09-381400

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac rehabilitation decreases plasma pentraxin 3 in patients with cardiovascular diseases.2011

    • Author(s)
      Fukuda T, Kurano M, Iida H, Takano H, Tanaka T, Yamamoto Y, Ikeda K, Nagasaki M, Monzen K, Uno K, Kato M, Shiga T, Maemura K, Masuda N, Yamashita H, Hirata Y, Nagai R, Nakajima T.
    • Journal Title

      Eur J Cardiovasc Prev Rehabil

      Volume: Sep 13

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 二光子生体分子イメージングによる生活習慣病の病態解明2013

    • Author(s)
      西村智、長崎実佳、小室一成、永井良,長崎実佳,西村智、小室一成、永井良三
    • Organizer
      システム疾患生命科学による先端医療技術開発シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-02-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation Associated with Obesity (Featured Reserach Session)2013

    • Author(s)
      Nisimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Komuro I, Nagai R Nagasaki M, Nishimura S, Manabe I, Uno K, Yamashita H, Nagai R, Sugita J, Nishimura S, Nagasaki M, Nagai R, Komuro i
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織2013

    • Author(s)
      西村智,長崎実佳,真鍋一郎,江藤浩之,門脇孝、永井良三,小室一成
    • Organizer
      糖尿病・肥満動物学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体二光子分子イメージングによる生活習慣病病態解析2013

    • Author(s)
      西村智,長崎実佳,真鍋一郎,江藤浩之,永井良三
    • Organizer
      第33回レーザー学会年次大会
    • Place of Presentation
      姫路
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Autotaxin Contributes to the Adipose Tissue Expansion and Inflammation in Diet-induced-obesity in Mice2013

    • Author(s)
      Nagasaki M, Nishimura S, Manabe I, Uno K, Yamashita H, Nagai R, Komuro I
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Malfunction and Infiltration of Inflammatory Monocytes in Skeletal Muscle from Obese Mice2013

    • Author(s)
      Sugita J, Nishimura S, Nagasaki M, Nagai R, Komuro i
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織における免疫・炎症細胞のクロストーク2013

    • Author(s)
      西村智, 長崎実佳, 真鍋一郎, 江藤浩之, 門脇孝、永井良三,小室一成
    • Organizer
      糖尿病・肥満動物学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 二光子生体分子イメージングによる生活習慣病の病態解明2013

    • Author(s)
      西村 智、長崎 実佳、小室 一成、永井 良三
    • Organizer
      システム疾患生命科学による先端医療技術開発 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂質生合成酵素オートタキシンはメタボリックシンドローム病態に寄与する2013

    • Author(s)
      長崎 実佳, 西村 智、小室 一成、永井 良三
    • Organizer
      システム疾患生命科学による先端医療技術開発 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 百聞は一見に如かず-基礎・臨床領域におけるイメージングの最前線-」生体分子イメージングでみる生活習慣病における免疫・炎症細胞の相互作用2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第12回日本抗加齢医学会総会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生医療に貢献する技術生体分子イメージングでみる免疫・炎症・再生細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第11回再生医療学会総パネルディスカッション
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体二光子イメージングでみる生活習慣病における免疫・炎症細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      分子イメージング学会第7回学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Brinkhous Young Investigator Prize in Thrombosis Finalist Discoid Platelet Aggregations Visualized by In Vivo Molecular Imaging without Endothelium Disruption, and Contribution of Inflammatory Cytokine, Ros, and Integrin Signaling2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R, Kenneth M
    • Organizer
      ATVB session 2012
    • Year and Date
      2012-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Singapore In vivo multi-photon molecular imaging technique reveals inflammatory cell cross-talks in adult common diseases2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      Focus on Microscopy 2012
    • Year and Date
      2012-04-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Symposium Metabolic Syndrome and Obesity In vivo multi-photon molecular imaging technique visualizes immune cell cross-talks in metabolic diseases2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      第20回日本血管生物医学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling in vivo2012

    • Author(s)
      Nishimura S, Nagasaki M, Eto K
    • Organizer
      HAA 2012 Annual Scientific Meeting APSTH symposium
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling in vivo2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R
    • Organizer
      HAA 2012 Annual Scientific Meeting APSTH symposium (Invited)
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo multi-photon molecular imaging technique visualizes parenchymal and interstitial cell cross-talks in adult metabolic and thrombotic disease, (YIA finalist)2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      The Asian-Pacific Society of Atherosclerosis and Vascular Diseases Committee (APSAVD)
    • Place of Presentation
      Phuket
    • Related Report
      2012 Final Research Report
  • [Presentation] Discoid platelet aggregations visualized by in vivo molecular imaging, and contribution of inflammatory cytokines2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R
    • Organizer
      MLTD 2012 22nd International Congres on Thrombosis
    • Place of Presentation
      Nice
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo multi-photon molecular imaging visualizes inflammatory and immune cell cross-talks in adult common disease2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      European Microscopy Congress 2012
    • Place of Presentation
      Manchester
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体二光子イメージングでみる生活習慣病における免疫・炎症性細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      バイオイメージング学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] In vivo multi-photon molecular imaging technique visualizes parenchymal and interstitial cell cross-talks in adult common and chronic inflammatory disease (Best Picture Awards)2012

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Nagai R
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] メタボリックシンドローム最新情報ー腸管免疫と慢性炎症ー」生体分子イメージングでみる肥満脂肪組織における免疫・炎症細胞・腸管のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第44回日本動脈硬化学会総会・学術集会パネルディスカッション
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体分子イメージングでみる生活習慣病における免疫・炎症細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      炎症再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織における免疫・炎症細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織における免疫・炎症細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      日本顕微鏡学会第68回学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Bangkok In vivo multi-photon molecular imaging technique reveals inflammatory and immune cell cross-talks in adult common disease (Best Presentation Awardy)2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      The 1st Annual International Meeting of The Society of Molecular Imaging
    • Related Report
      2012 Final Research Report
  • [Presentation] Symposium Metabolic Syndrome and Obesity In vivo multi-photon molecular imaging technique visualizes immune cell cross-talks in metabolic diseases2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      第20回日本血管生物医学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Discoid platelet aggregations visualized by in vivo molecular imaging, and contribution of inflammatory cytokines2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R
    • Organizer
      HAA 2012 Annual Scientific Meeting APSTH symposium
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In vivo multi-photon molecular imaging technique visualizes parenchymal and interstitial cell cross-talks in adult metabolic and thrombotic disease, (YIA finalist)2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      The Asian-Pacific Society of Atherosclerosis and Vascular Diseases Committee (APSAVD)
    • Place of Presentation
      Phuket, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Discoid platelet aggregations visualized by in vivo molecular imaging, and contribution of inflammatory cytokines2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R
    • Organizer
      MLTD 2012 22nd International Congres on Thrombosis
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo multi-photon molecular imaging visualizes inflammatory and immune cell cross-talks in adult common disease2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      European Microscopy Congress 2012
    • Place of Presentation
      Manchester, England
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo multi-photon molecular imaging technique visualizes parenchymal and interstitial cell cross-talks in adult common and chronic inflammatory disease (Best Picture Awards)2012

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Nagai R
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] パネルディスカッション2「メタボリックシンドローム最新情報ー腸管免疫と慢性炎症ー」 生体分子イメージングでみる肥満脂肪組織における免疫・炎症細胞・腸管のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第44回 日本動脈硬化学会 総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム 「百聞は一見に如かず -基礎・臨床領域におけるイメージングの最前線-」 生体分子イメージングでみる生活習慣病における免疫・炎症細胞の相互作用2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] パネルディスカッション 再生医療に貢献する技術 生体分子イメージングでみる免疫・炎症・再生細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第11回再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体二光子イメージングでみる生活習慣病における免疫・炎症細胞のクロストーク (最優秀賞)2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      分子イメージング学会第7回学術集会
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] 写真コンクール 生体分子イメージングでみる肥満と血栓形成過程2012

    • Author(s)
      西村智、長崎実佳
    • Organizer
      日本顕微鏡学会第68回学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
  • [Presentation] Discoid Platelet Aggregations Visualized by In Vivo Molecular Imaging without Endothelium Disruption, and Contribution of Inflammatory Cytokine, Ros, and Integrin Signaling2012

    • Author(s)
      Nishimura S, Nagasaki M, Nagai R
    • Organizer
      ATVB session 2012, Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Finalist
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo multi-photon molecular imaging technique reveals inflammatory and immune cell cross-talks in adult common disease (Best Presentation Awardy)2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      The 1st Annual International Meeting of The Society of Molecular Imaging
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo multi-photon molecular imaging technique reveals inflammatory cell cross-talks in adult common diseases2012

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      Focus on Microscopy 2012
    • Place of Presentation
      Singapore, Republic of Singapore
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体分子イメージングでみる生活習慣病における免疫細胞のクロストーク2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      第21回東京免疫フォーラム
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織炎症と局所免疫異常、T・B・マクロファージの相互作用2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、門脇孝、永井良三
    • Organizer
      糖尿病肥満動物学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体二光子イメージングによる慢性炎症下の病態解析2012

    • Author(s)
      西村智、長崎実佳、真鍋一郎、江藤浩之、永井良三
    • Organizer
      レーザー学会学術講演会第32回年次大会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織 における慢性炎症・局所免疫異常2011

    • Author(s)
      西村智, 長崎実佳, 真鍋一郎, 江藤浩之, 門脇孝,永井良三
    • Organizer
      40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織炎症と局所免疫異常2011

    • Author(s)
      西村智, 長崎実佳, 真鍋一郎, 江藤浩之, 門脇孝,永井良三
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規生体分子イメージングによる血栓形成過程の解明及び骨髄免疫応答の可視化2011

    • Author(s)
      西村 智, 長崎 実佳, 真鍋 一郎, 江藤 浩之, 永井 良三
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織における慢性炎症・局所免疫2011

    • Author(s)
      西村智, 長崎実佳, 真鍋一郎, 江藤浩之, 永井良三
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路
    • Related Report
      2011 Research-status Report
  • [Presentation] オートタキシンはメタボリックシンドローム・悪性腫瘍の診断に有用なバイオマーカーである2011

    • Author(s)
      長崎実佳, 西村智, 林直人, 真鍋一郎, 大川龍之介, 中村和宏,宇野漢成, 矢冨裕, 永井良三
    • Organizer
      第52回人間ドック学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングによる血栓形成素過程の解析2011

    • Author(s)
      西村 智, 長崎 実佳, 真鍋 一郎, 江藤 浩之, 永井 良三
    • Organizer
      第9回血液・血管オルビス
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Adipose Tissue Remodeling and Malfunctioning in Obesity Based on Chronic Inflammation and Abnormal Local Immunity2011

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] In Vivo Molecular Imaging Reveals Multi-cellular Kinetics of Developing Thrombus2011

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo molecular imaging reveals multi-cellular kinetics of developing thrombus and underlying mechanisms2011

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Nagai R
    • Organizer
      the XXIII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo imaging reveals inflammatory processes of adult common diseases2011

    • Author(s)
      西村 智, 長崎 実佳, 真鍋 一郎, 江藤 浩之, 永井 良三
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体二光子イメージングによる慢性炎症下の病態解析 : 生活習慣病病態の解明を目指して2011

    • Author(s)
      西村 智, 長崎実佳, 真鍋一郎, 江藤浩之, 永井良三
    • Organizer
      レーザ顕微鏡研究会
    • Place of Presentation
      和光市
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo molecular imaging reveals inflammatory processes in adult common diseases: from metabolic syndrome to thrombosis2011

    • Author(s)
      Nishimura S, Nagasaki M, Manabe I, Eto K, Nagai R
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo multi-photon molecular imaging technique reveals parenchymal and interstitial cell cross-talks in chronic inflammatory disease: from metabolic syndrome to thrombosis2011

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      6th European Molecular Imagig Meeting
    • Place of Presentation
      Leiden (Netherlands)
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングでみる肥満脂肪組織炎症・局所免疫異常2011

    • Author(s)
      西村 智, 長崎 実佳, 真鍋 一郎, 江藤 浩之, 門脇 孝,永井 良三
    • Organizer
      54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体分子イメージングによる生活習慣病病態の解析:慢性炎症を背景とする実質と間質の相互作用 In vivo molecular imaging reveals inflammatory cell cross-talks in adult common diseases2011

    • Author(s)
      西村 智, 長崎 実佳, 真鍋 一郎, 江藤 浩之, 永井 良三
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 血清リン脂質・生合成系を標的とした新規メタボリックシンドロームマーカーの探索2011

    • Author(s)
      西村智, 長崎実佳, 真鍋一郎,中村和宏, 大川龍之介, 宇野漢成, 矢冨裕、林直人, 永井良三
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo multi-photon molecular imaging technique reveals parenchymal and interstitial cell cross-talks in chronic inflammatory disease: from metabolic syndrome to thrombosis2011

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      the Cold Spring Harbor Asia Conference on New Advances in Optical Imaging of Live Cells and Organisms
    • Place of Presentation
      China(Suzhou)
    • Related Report
      2011 Research-status Report
  • [Presentation] Adipose tissue remodeling and malfunctioning in obesity based on chronic inflammation and abnormal immunity2011

    • Author(s)
      Nishimura S, Nagasaki M
    • Organizer
      4th International Congress on Prediabetes and the Metabolic Syndrome
    • Place of Presentation
      Spain(Marid)
    • Related Report
      2011 Research-status Report
  • [Book] 生体二光子イメージングによる慢性炎症下の病態解析:生活習慣病の病態解明を目指して2012

    • Author(s)
      西村 智, 長崎実佳
    • Publisher
      Medical Science Digest
    • Related Report
      2012 Annual Research Report
  • [Book] Medical Science Digest2011

    • Author(s)
      西村 智, 長崎実佳
    • Total Pages
      2
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2011 Research-status Report
  • [Book] 最新医学2011

    • Author(s)
      西村智、長崎実佳
    • Total Pages
      7
    • Publisher
      最新医学社
    • Related Report
      2011 Research-status Report
  • [Book] 化学と生物2011

    • Author(s)
      西村 智、長崎 実佳
    • Total Pages
      7
    • Publisher
      日本農芸化学会会
    • Related Report
      2011 Research-status Report
  • [Book] Journal of Biorheology2011

    • Author(s)
      Nishimura S, Nagasaki M
    • Total Pages
      5
    • Publisher
      日本バイオレオロジー学会
    • Related Report
      2011 Research-status Report
  • [Book] 血管医学2011

    • Author(s)
      西村 智、長崎 実佳
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Research-status Report
  • [Book] 臨床検査2011

    • Author(s)
      西村 智、長崎 実佳
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2011 Research-status Report
  • [Book] モデル動物利用マニュアル 疾患モデルの作製と利用 循環器疾患2011

    • Author(s)
      西村 智、長崎 実佳
    • Total Pages
      8
    • Publisher
      LIC社
    • Related Report
      2011 Research-status Report
  • [Book] 月刊「Heart View」2011

    • Author(s)
      西村 智、長崎 実佳
    • Total Pages
      9
    • Publisher
      MEDICAL VIEW社
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.invivoimaging.net/

    • Related Report
      2012 Final Research Report
  • [Remarks] welcome to nishimura's labo

    • URL

      http://www.invivoimaging.net/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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