Screening for therapies of diabetes targeting novel hepatokine selenoprotein P that induces insulin resistance
| Project/Area Number |
23791022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Kanazawa University |
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Principal Investigator |
MISU Hirofumi 金沢大学, 医薬保健学総合研究科, 特任助教 (80447680)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エネルギー / 糖代謝異常 / ヘパトカイン |
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| Research Abstract |
Antidiabetic drug metformin was shown to reduce selenoprotein P gene expression via AMP kinase/Foxo3 pathway in the cultured hepatocytes. Membrane protein X was identified as a strong candidate of the receptor of selenoprotein P in C2C12 myocytes. It is expected that AMPK/Foxo3 pathway in the liver and seenoprotein P/membrane protein 1 pathway in the muscle are novel therapeutic targets for type 2 diabetes.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver2013
Author(s)
T Otoda, T Takamura, H Misu, T Ota, S Murata, H Hayashi, H Takayama, A Kikuchi, T Kanamori, KR Shima, F Lan, T Takeda, S Kurita, K Ishikura, Y Kita, K Iwayama, KI Kato, M Uno, Y Takeshita, M Yamamoto, K Tokuyama, S Iseki, K Tanaka, S Kaneko
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Journal Title
Diabetes
Volume: 62(3)
Issue: 3
Pages: 811-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis2012
Author(s)
Y Kita, T Takamura, H Misu, T Ota, S Kurita, Y Takeshita, M Uno, N Matsuzawa-Nagata, K Kato, H Ando, A Fujimura, K Hayashi, T Kimura, Y Ni, T Otoda, K Miyamoto, Y Zen, Y Nakanuma, S Kaneko
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Journal Title
PLoS One
Volume: 7(9)
Issue: 9
Pages: e43056-e43056
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes : Assessment using a meal tolerance test under clinical conditions2012
Author(s)
H Ando, S Kurita, A Shimizu, K Kato, K Ishikura, K Taji, M Uno, Y Takeshita, H Misu, A Fujimura, S Kaneko, T Takamura
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Journal Title
Clin Exp Pharmacol Physiol
Volume: 39(6)
Issue: 6
Pages: 528-34
DOI
NAID
Related Report
Peer Reviewed
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