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Generation of pancreatic beta cell from human pluripotent stem cell by use of the purification with flow cytometry

Research Project

Project/Area Number 23791025
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionKyoto University

Principal Investigator

TOYODA Taro  京都大学, iPS 細胞研究所, 特定拠点助教 (60593530)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医学 / エネルギー / 糖質代謝異常 / PDX1 / 膵臓β細胞 / インスリン / 糖尿病 / iPS 細胞 / 膵臓 / β細胞 / iPS細胞
Research Abstract

Cell therapy using pancreatic ・cells generated from human pluripotent stem cells (hPSCs) is one of the possible solutionsof diabetes problems. Since the generation of target cell types from PSCs with high purity is currently difficult, it is necessary to isolate differentiated pancreatic cells for accurate analysis. In this study, we generated a human iPS cell line in which the fluorescent protein reporter gene is expressed under the control of the promoter of PDX1 gene, a key transcriptional factor for pancreatic development and function. This cell line is useful to analyze pancreatic cells derived from hPSCs

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012

All Journal Article (2 results) Presentation (1 results) Book (2 results)

  • [Journal Article] 多能性幹細胞からの膵β細胞の分化誘導2012

    • Author(s)
      長船健二, 豊田太郎
    • Journal Title

      代謝系臓器 (再生医療叢書), 朝倉書店

      Pages: 39-47

    • Related Report
      2012 Final Research Report
  • [Journal Article] iPS 細胞による膵島再生の現状と未来, 別冊「プラクティス」 ブリットル糖尿病の病態と治療・管理のコツ 進化する治療・広がる未来2012

    • Author(s)
      長船健二, 豊田太郎
    • Journal Title

      医歯薬出版株式会社

      Pages: 184-185

    • Related Report
      2012 Final Research Report
  • [Presentation] 病態解析に向けたヒト iPS/ES 細胞から膵外分泌細胞への高効率分化誘導法の開発2012

    • Author(s)
      舩戸道徳, 豊田太郎, 近藤恭士, 細川吉弥,須藤智美, 沖田圭介, 浅香勲, 上杉志成, 加藤善一郎, 太田章, 山中伸弥, 近藤直実, 長船健二
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Book] 代謝系臓器 (再生医療叢書)2012

    • Author(s)
      日本再生医療学会 (監修)
    • Total Pages
      212
    • Publisher
      朝倉書店
    • Related Report
      2012 Annual Research Report
  • [Book] 別冊「プラクティス」 ブリットル糖尿病の病態と治療・管理のコツ2012

    • Author(s)
      植木浩二郎 (編集)
    • Total Pages
      180
    • Publisher
      医歯薬出版
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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