The role of Src on pancreatic β-cells and its relationship to GPCRsignal
Project/Area Number |
23791028
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Chiba University (2012) Kyoto University (2011) |
Principal Investigator |
MUKAI Eri 千葉大学, 大学院・医学研究院, 講師 (60362539)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | エネルギー / 糖質代謝異常 / 糖尿病 / 糖代謝 / インスリン分泌 |
Research Abstract |
We have previously showed that Src activation induces ROS production and impaired insulin secretion in diabetic β-cells and GPCR ligand could suppress the Src activation and ROS production. The present study revealed that Src is involved in glucose-induced insulin secretion and its augmentation by GPCR ligand in normal state and the effect of Src is through glucokinase regulation, indicating that Src is important for insulin secretary mechanism of β-cells.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction2013
Author(s)
Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N.
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Journal Title
Diabetes
Volume: ahead of print
Related Report
Peer Reviewed
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[Journal Article] Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction.2013
Author(s)
Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N.
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Journal Title
Diabetes
Volume: ahead of print
Related Report
Peer Reviewed
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[Journal Article] Role of Mitochondrial Phosphate Carrier in Metabolism-Secretion Coupling in Rat Insulinoma Cell Line INS-1.2011
Author(s)
Nishi, Y., Fujimoto, S., Sasaki, M., Mukai, E., Sato, H., Sato, Y., Tahara, Y., Nakamura, Y., Inagaki, N.
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Journal Title
Biochemical Journal
Volume: 435(2)
Pages: 421-430
Related Report
Peer Reviewed
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[Presentation] procyanidinsinprove glucose tolerance in diabetic ob/ob mice2012
Author(s)
Ogura K, Nagashima K, Shoji T, Sato Y, Tahara Y, Yamano G, Sato H, Ogura M, Mukai E, Fujimoto S, Inagaki N. Apple
Organizer
9^<th> International Diabetes Federation Western Pacific Region Congress and 4^<th> Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Development of 123I-labeled derivative targeting to GLP-1 receptor for insulinoma SPECT imaging2012
Author(s)
Zhuang X, Toyoda K, Fujimoto H, Kimura H, Ogawa Y, Mukai E, Ueda M, Temma T, Hirai M, Takagi M, Kon A, Matsuda H, Ono M, Saji H, Inagaki N.
Organizer
9^<th> International Diabetes Federation Western Pacific Region Congress and 4^<th> Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Src regulates insulin secretion by modulating glucokinase activity in INS-1 cells2012
Author(s)
Sato S, Fujimoto S, Nagashima K, Mukai E, Ogura M, Sato Y, Yamano G, Tahara Y, Ogura K, Sugizaki K, Inagaki N.
Organizer
9^<th> International Diabetes Federation Western Pacific Region Congress and 4^<th> Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Development of non-invasive PET probe for quantifying pancreatic b-cell mass usingfluorine-18-labeled exendin-42012
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Ueda M, Temma T, Hirai M, Matsuda H, Saji H, Inagaki N.
Organizer
9^<th> International Diabetes Federation Western Pacific Region Congress and 4^<th> Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Apple procyanidinsinprove glucose tolerance in diabetic ob/ob mice.2012
Author(s)
Ogura K, Nagashima K, Shoji T, Sato Y, Tahara Y, Yamano G, Sato H, Ogura M, Mukai E, Fujimoto S, Inagaki N.
Organizer
9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Development of 123I-labeled derivative targeting to GLP-1 receptor for insulinoma SPECT imaging.2012
Author(s)
Zhuang X, Toyoda K, Fujimoto H, Kimura H, Ogawa Y, Mukai E, Ueda M, Temma T, Hirai M, Takagi M, Kon A, Matsuda H, Ono M, Saji H, Inagaki N.
Organizer
9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Src regulates insulin secretion by modulating glucokinase activity in INS-1 cells.2012
Author(s)
Sato S, Fujimoto S, Nagashima K, Mukai E, Ogura M, Sato Y, Yamano G, Tahara Y, Ogura K, Sugizaki K, Inagaki N.
Organizer
9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Development of non-invasive PET probe for quantifying pancreatic b–cell mass using fluorine-18-labeled exendin-4.2012
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Ueda M, Temma T, Hirai M, Matsuda H, Saji H, Inagaki N.
Organizer
9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto
Related Report
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[Presentation] Development of non-invasive PET probe for quantifying pancreatic β-cell mass using fluorine-18-labeled exendin-42011
Author(s)
Toyoda K, Kimura H, Fujimoto H, Zhuang X, Mukai E, Ogawa Y, Hirao K, Matsuda H, Kawashima H, Ueda M, Temma T, Saji H, Inagaki N.
Organizer
71th Scientific Sessions of AmericanDiabetes Association
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Non-invasive SPECT imaging of pancreatic islets targeting glucagon-like peptide-1 receptors2011
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Kawashima H, Matsuda H, Hirao K, Saji H, Inagaki N.
Organizer
71th Scientific Sessions of American Diabetes Association
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Development of non-invasive PET probe for quantifying pancreatic b-cell mass using fluorine-18-labeled exendin-4.2011
Author(s)
Toyoda, K., Kimura, H., Fujimoto, H., Zhuang, X., Mukai, E., Ogawa, Y., Hirao, K., Matsuda, H., Kawashima, H., Ueda. M., Temma, T., Saji, H., Inagaki, N.
Organizer
71th Scientific Sessions of American Diabetes Association
Place of Presentation
San Diego
Related Report
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[Presentation] Non-invasive SPECT imaging of pancreatic islets targeting glucagon-like peptide-1 receptors.2011
Author(s)
Fujimoto, H., Toyoda, K., Kimura, H., Ogawa, Y., Mukai, E., Zhuang, X., Kawashima, H., Matsuda, H., Hirao, K., Saji, H., Inagaki, N.
Organizer
71th Scientific Sessions of American Diabetes Association
Place of Presentation
San Diego
Related Report
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[Presentation] Role of Mitochondrial Phosphate Carrier in Metabolism-Secretion Coupling in Rat Insulinoma Cell Line INS-1.2011
Author(s)
Nishi, Y., Fujimoto, S. , Sasaki, M., Mukai, E., Sato, H., Sato, Y., Tahara, Y., Nakamura, Y., Inagaki, N.
Organizer
16th Japan-Korea Symposium on Diabetes Mellitus
Place of Presentation
Tokyo
Related Report
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