Study of clinical implication of a novel G protein-coupled receptor GPR119: its possible role in glucose homeostasis
Project/Area Number |
23791030
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Kyoto University |
Principal Investigator |
ODORI Shinji 京都大学, 医学研究科, 客員研究員 (30402879)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | GPR119 / エンドカンナビノイド / 内因性脂質 / 摂食調節 / 糖代謝調節 / 膵臓腸管内分泌ネットワーク |
Research Abstract |
To assess clinical implications of GPR119, the present study was designed to elucidate the distribution of GPR119 gene expressionin humans. GPR119 mRNA expression was measured in fresh human tissues collected at surgery. GPR119 mRNA was detected most abundantly in the pancreas, followed by the duodenum, stomach, jejunum, ileum and colon. GPR119 mRNA in pancreatic islets was enriched more than 10-fold as compared with adjacent pancreatic tissue and its level was comparable to that of GPR40 mRNA, which is highly expressed in human pancreatic islets. GPR119 mRNA was also abundant in two cases of insulinoma and two cases of glucagonoma, but was undetectable in a pancreatic acinar cell tumor. The present study demonstrates that GPR119 mRNA is abundantly expressed in human pancreatic islets and gastrointestinal tract, as well as in human insulinomas and glucagonomas, indicating islet-gastrointestinal distribution of GPR119 and its expression in pancreatic beta and alpha cells, as well as the possible involvement in islet functions in humans.
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Report
(3 results)
Research Products
(10 results)
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[Presentation] 新規のG蛋白共役型-脂質受容体GPR119の臨床的意義:ヒトおよびマウスでの膵島における遺伝子発現と膵島機能との連関2011
Author(s)
小鳥真司, 冨田努, 孫徹, 藤倉純二, 野口倫生, 森栄作, 内藤雅喜, 日下部徹, 海老原健, 細田公則, 中尾一和
Organizer
第54回日本糖尿病学会年次学術集会
Place of Presentation
札幌プリンスホテル(北海道)
Related Report
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[Presentation] G蛋白共役型-脂肪酸受容体GPR40の遺伝性肥満モデルの膵島での発現調節2011
Author(s)
小鳥真司, 冨田努, 孫 徹, 藤倉純二, 野口倫生, 森栄作, 内藤雅喜, 日下部徹, 海老原健, 細田公則,中尾一和
Organizer
第32回日本肥満学会学術集会
Place of Presentation
兵庫県立淡路夢舞台国際会議場(兵庫県)
Related Report
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