The role of prolyl isomerase Pin1 in energy metabolism
| Project/Area Number |
23791034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
NAKATSU Yusuke 広島大学, 大学院・医歯薬保健学研究院, 助教 (20452584)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Pin1 / NASH / KOマウス / 結合蛋白 |
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| Research Abstract |
I investigated the role of Pin1 in nonalcoholic steatohepatitis (NASH), using Pin1 KO mice. Pin1 KO mice showthe resistance to fatty liver, cytokine inflammation and fibrosis. These results indicate that Pin1 is an important regulator of NASH.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Ki kuch T, Fukushi ma T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 287(53)
Pages: 44526-35
Related Report
Peer Reviewed
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[Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development.2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, et al.,
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 32
Pages: 291-298
Related Report
Peer Reviewed
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