Role of cAMP response element binding (CREB) coactivator CRTC3 on adipogenesis

• Project/Area Number: 23791037
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: IGATA Motoyuki 熊本大学, 医学部附属病院, 特任助教 (40599099)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: メタボリックシンドローム / CRTC3 / 脂肪細胞 / 脂肪細胞分化

Research Abstract

It is known that cAMP-CREB signal has a role in adipocyte differentiation and lipolysis.We studied the role of CREB co-activator CRTC3 in adipocyte, especially on adipogenesis.In this project, we showed that adipocyte differentiation was inhibited by knockdown ofCRTC3 in 3T3L1 cells. In the promoter analysis of CRTC3 gene, CRTC3 promoter has a cAMPresponsive element (CRE) and is regulated positively by itself through the CRE.

Research Products

• [Journal Article] Regulation of TNFαconverting enzyme activity in visceraladipose tissue of obese mice (2013)
  • Author(s): Kawasaki S, Motoshima H, Hanatani S,Takaki Y, Igata M, Tsutsumi A, MatsumuraT, Kondo T, Senokuchi T, Ishii N, KinoshitaH , F uku da K, Kaw ash ima J, Shi mod a S ,Nishikawa T, Araki E
  • Journal Title: Biochem Biophys Res Commun Volume: 430 Pages: 1189-94
  • Peer Reviewed
• [Journal Article] Regulation of TNFa converting enzyme activity in visceral adipose tissue of obese mice (2013)
  • Author(s): Shuji Kaeasaki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 430 Pages: 1189-1194
  • Peer Reviewed
• [Journal Article] Caroric restrictiondecreases ER stress in liver and adiposetissue in ob/ob mice (2011)
  • Author(s): Tsutsumi A, Motoshima H, Kondo T,Kawasaki S, Matsumura T, Hanatani S, IgataM, Ishii N, Kinoshita H, Kawashima J,Taketa K, Furukawa N, Tsuruzoe K,Nishikawa T, Araki E
  • Journal Title: Biochem Biophys ResCommun Volume: 404 Pages: 339-344
  • Peer Reviewed
• [Presentation] DPP-4 阻害薬による尿中アルブミン増加阻止 -直接的な腎保護作用の可能性 (2013)
  • Author(s): 井形元維、本島寛之、川崎修二、花谷聡子、高木優樹、水流添覚、西川武志、荒木栄一
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: メルパルク熊本(熊本市)
  • Year and Date: 2013-05-18
• [Presentation] DPP-4阻害薬による尿中アルブミン増加阻止 –直接的な腎保護作用の可能性- (2013)
  • Author(s): 井形元維
  • Organizer: 第56回日本糖尿病学会総会
  • Place of Presentation: 熊本 メルパルク熊本
• [Presentation] 悪性腫瘍合併糖尿病患者における血糖コントロール指標としての血中可溶性インスリン受容体の意義 (2012)
  • Author(s): 井形元維、本島寛之、湯浅智之、近藤龍也、河島淳司、松村剛、前田貴子、川崎修二、花谷聡子、石井規夫、下田誠也、古川昇、西川武志、蛯名洋介、荒木栄一
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2012-05-19
• [Presentation] 悪性腫瘍合併糖尿病患者における血糖コントロール指標としての血中可溶性インスリン受容体の意義 (2012)
  • Author(s): 井形元維
  • Organizer: 第55回日本糖尿病学会総会
  • Place of Presentation: 横浜 パシフィコ横浜