Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
It is known that cAMP-CREB signal has a role in adipocyte differentiation and lipolysis.We studied the role of CREB co-activator CRTC3 in adipocyte, especially on adipogenesis.In this project, we showed that adipocyte differentiation was inhibited by knockdown ofCRTC3 in 3T3L1 cells. In the promoter analysis of CRTC3 gene, CRTC3 promoter has a cAMPresponsive element (CRE) and is regulated positively by itself through the CRE.
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