For clinical application of glucokinase activator
Project/Area Number |
23791040
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Yokohama City University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | グルコキナーゼ / 膵β細胞量 |
Research Abstract |
We investigated the mechanisms by which glucokinase activator (GKA) stimulates beta cell function and proliferation and we then explored therapeutic strategy by which GKA worked more effectively. GKA-stimulated Irs2 expression affected beta cell proliferation, but not beta cell function. Oxidative stress could diminish the effects of GKA on the changes in expression of genes involved in beta cell function and proliferation. A combination of GKA and an incretin-related agent might be effective.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Protection from nonalcoholic steatohepatitis and liver tumorigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.2012
Author(s)
Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y
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Journal Title
Diabetologia
Volume: 55(12)
Issue: 12
Pages: 3382-3391
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012
Author(s)
Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
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Journal Title
Endocrinology
Volume: 153(3)
Issue: 3
Pages: 1093-102
DOI
Related Report
Peer Reviewed
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