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Analysis of SIK3, newly regulator of glucose, lipid, cholesterol, and bile acid

Research Project

Project/Area Number 23791048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionOsaka University (2012)
独立行政法人医薬基盤研究所 (2011)

Principal Investigator

UEBI Tastuya  大阪大学, 大学院・生命機能研究科, 招へい研究員 (80513803)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsメタボリックシンドローム / 肥満 / 脂質代謝 / リン酸化 / コレステロール代謝
Research Abstract

SIK3-KO mice do not get fat, but were caused liver dysfunction. In order to develop the anti-obesity drug, in this study, a function of SIK3 was analyzed. SIK3-KO mice were high sensitive to bile acid, and the high bile acid level induced serious liver dysfunction. By analysis of gene expression level, it was found that SIK-KO mice lost the regulation of expression of gene related to cholesterol and bile acid responding a diet.It was suggested that SIK3 was master regulator of cholesterol and bile acid homeostasis. By mass spectrometry analysis of phosphorylatedproteins, two candidate target proteins of SIK3 were found. Since there was no difference in the fatty acid composition between SIK3-KO and wild type, it was suggested that fatty acid do not relate to energy reflux.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012

    • Author(s)
      Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e37803-e37803

    • DOI

      10.1371/journal.pone.0037803

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.2012

    • Author(s)
      Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N
    • Journal Title

      Development

      Volume: 139(6) Pages: 1153-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIK3 is essential forchondrocyte hypertrophy during skeletaldevelopment in mice2012

    • Author(s)
      Sasagawa,S.,Takemori,H.,Uebi,T.,Ikegami,D.,Hiramatsu,K.,Ikegawa,S.,Yoshikawa,H.and Tsumaki,N.
    • Journal Title

      Development

      Volume: 139巻 Issue: 6 Pages: 1153-1163

    • DOI

      10.1242/dev.072652

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] SIK3 はコレステロール、胆汁酸代謝の制御因子である2011

    • Author(s)
      上尾達也、伊東祐美、 熊谷彩子、竹森洋
    • Organizer
      第34回日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] SIK3はコレステロール-胆汁酸代謝の制御因子である2011

    • Author(s)
      上尾達也、伊東祐美、熊谷彩子、竹森洋
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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