crosstalk of C-type natriuretic peptide in the endochondral ossification

• Project/Area Number: 23791056
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Kyoto University
• Principal Investigator: FUJII Toshihito 京都大学, 医学(系)研究科(研究院), 助教 (50537347)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 軟骨 / ナトリウム利尿ペプチド / 骨 / 内分泌 / 骨代謝 / 成長板軟骨 / トランスレーショナルリサーチ / 軟骨代謝 / C型ナトリウム利尿ペプチド

Research Abstract

In this study, I showed that C-type natriuretic peptide(CNP) attenuated downstream signals of BMP in the endochondral ossification. Now, therefore, CNP may be the target of drug discovery for Fibrodysplasia Ossificans Progressiva(FOP), that is a refractory disease of muscle and bone caused by runaway of BMP signals.