For elucidation of the mechanism of pituitary gland tumorgenesis focused on BMP system and the development of the medicine cure
| Project/Area Number |
23791057
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Okayama University |
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Principal Investigator |
MIYOSHI Tomoko 岡山大学, 医療教育統合開発センター, 助教 (40444674)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体腫瘍 / 骨形成タンパク / クッシング病 / ソマトスタチン誘導体 / 視床下部 / メタスチン / 内分泌学 / 視床下部細胞 / 骨形成たんぱく / 骨形成蛋白 / 薬物治療 |
|---|
| Research Abstract |
BMP action was known in corticotrope cells as a negative regulator for the expression of an adrenocorticotropin (ACTH) precursor, proopiomelanocortin (POMC). In corticotrope cells, BMP response is upregulated by somatostatin analogs. Thus, somatostatin analogs suppress CRH-induced ACTH production in corticotrope cells.
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Report
(3 results)
Research Products
(47 results)
