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Roles of bone morphogenetic protein-6 inaldosterone regulation by adrenocortical cells

Research Project

Project/Area Number 23791058
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionOkayama University

Principal Investigator

TSUKAMOTO Naoko  岡山大学, 岡山大学病院, 助教 (90601302)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords内科学 / 内分泌 / 副腎 / ステロイド / 成長因子 / アルドステロン / BMP / エンドセリン
Research Abstract

In the present study, we examined the in vivo roleof BMP-6 in regulation of aldosterone by neutralizing endogenous BMP-6 in rats treated with immunization against BMP-6. It was suggested that endogenous BMP-6 is functionally linked to aldosterone synthesis in the adrenal cortex in vivo.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (32 results)

All 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 14 results) Presentation (12 results)

  • [Journal Article] Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling2013

    • Author(s)
      Matsumoto Y, Otsuka F, Takano-Narazaki M, Katsuyama T, Nakamura E, Tsukamoto N,Inagaki K, Sada KE, Makino H
    • Journal Title

      Steroids

      Volume: 78 Pages: 513-520

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis2013

    • Author(s)
      Nakamura E, Otsuka F, Inagaki K, Tsukamoto N,Ogura-Ochi K, Miyoshi T, Toma K, Takeda M, Makino H
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 134 Pages: 67-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling2013

    • Author(s)
      Yoshinori Matsumoto,Fumio Otsuka, Mariko Takano-Narazaki, Takayuki Katsuyama, Eri Nakamura, Naoko Tsukamoto, Kenichi Inagaki, Ken-ei Sada, Hirofumi Makino.
    • Journal Title

      Steroids

      Volume: vol.78 Issue: 5 Pages: 513-520

    • DOI

      10.1016/j.steroids.2013.02.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland2012

    • Author(s)
      Matsumoto Y, Otsuka F, Inagaki K, Tsukamoto N,Takano-Narazaki M, Miyoshi T, Nakamura E, Ogura-Ochi K, Takeda M, Makino H
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 132 Pages: 8-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells2012

    • Author(s)
      Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H
    • Journal Title

      Mol Cell Endocrinol

      Volume: 358 Pages: 18-26

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys2012

    • Author(s)
      Suzuki J, Otsuka F, Matsumoto Y, Inagaki K, Miyoshi T, Takeda M, Tsukamoto N,Nakamura E, Ogura K, Makino H
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 312-7

    • NAID

      10030644434

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells2012

    • Author(s)
      Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Matsumoto Y, Ogura K, Tsukamoto N, Takeda M, Makino H
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 2012-2012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells2012

    • Author(s)
      Otsuka F, Tsukamoto N, Miyoshi T, Iwasaki Y, Makino H
    • Journal Title

      Mol Cell Endocrinol

      Volume: 349 Pages: 105-10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-a2012

    • Author(s)
      Takano M, Otsuka F, Matsumoto Y, Inagaki K, Takeda M, Nakamura E, Tsukamoto N,Miyoshi T, Sada KE, Makino H
    • Journal Title

      Mol Cell Endocrinol

      Volume: 348 Pages: 224-32

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LssT2 gonadotrope cells2012

    • Author(s)
      Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N,Makino H, Lawson MA
    • Journal Title

      Mol Cell Endocrinol

      Volume: 348 Pages: 147-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis2012

    • Author(s)
      Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Kanako Ogura-Ochi, Tomoko Miyoshi, Kishio Toma, Masaya Takeda, Hirofumi Makino
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: vol.134 Pages: 67-74

    • DOI

      10.1016/j.jsbmb.2012.10.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland2012

    • Author(s)
      Yoshinori Matsumoto, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Mariko Takano-Narazaki, Tomoko Miyoshi, Eri Nakamura, Kanako Ogura-Ochi, Masaya Takeda, Hirofumi Makino
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: in press Issue: 1-2 Pages: 8-14

    • DOI

      10.1016/j.jsbmb.2012.04.004

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys.2012

    • Author(s)
      Jiro Suzuki, Fumio Otsuka, Yoshinori Matsumoto, Kenichi Inagaki, Tomoko Miyoshi, Masaya Takeda, Naoko Tsukamoto, Eri Nakamura, Kanako Ogura, Hirofumi Makino
    • Journal Title

      Hypertension Research

      Volume: vol.35 Issue: 3 Pages: 312-317

    • DOI

      10.1038/hr.2011.186

    • NAID

      10030644434

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells.2012

    • Author(s)
      Fumio Otsuka, Naoko Tsukamoto, Tomoko Miyoshi, Yasumasa Iwasaki, Hirofumi Makino
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: vol.349 Issue: 2 Pages: 105-110

    • DOI

      10.1016/j.mce.2011.10.017

    • Related Report
      2011 Research-status Report
  • [Journal Article] Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells.2012

    • Author(s)
      Tomoko Miyoshi, Fumio Otsuka, Eri Nakamura, Kenichi Inagaki, Kanako Ogura-Ochi, Naoko Tsukamoto, Masaya Takeda, Hirofumi Makino
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: in press

    • Related Report
      2011 Research-status Report
  • [Journal Article] Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.2012

    • Author(s)
      Mariko Takano, Fumio Otsuka, Yoshinori Matsumoto, Kenichi Inagaki, Masaya Takeda, Eri Nakamura, Naoko Tsukamoto, Tomoko Miyoshi, Ken-ei Sada, Hirofumi Makino
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: vol.348 Issue: 1 Pages: 224-232

    • DOI

      10.1016/j.mce.2011.08.027

    • NAID

      120005232493

    • Related Report
      2011 Research-status Report
  • [Journal Article] Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.2012

    • Author(s)
      Masaya Takeda, Fumio Otsuka, Hiroaki Takahashi, Kenichi Inagaki, Tomoko Miyoshi, Naoko Tsukamoto, Hirofumi Makino, Mark A. Lawson
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: vol.348 Issue: 1 Pages: 147-154

    • DOI

      10.1016/j.mce.2011.08.001

    • Related Report
      2011 Research-status Report
  • [Journal Article] Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells.2012

    • Author(s)
      Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Tomoko Miyoshi, Yoshinori Matsumoto, Kanako Ogura, Naoko Tsukamoto, Masaya Takeda, Hirofumi Makino
    • Journal Title

      Endocrinology

      Volume: vol.153 Issue: 1 Pages: 469-480

    • DOI

      10.1210/en.2011-1646

    • Related Report
      2011 Research-status Report
  • [Journal Article] Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells2011

    • Author(s)
      Tsukamoto N, Otsuka F, Miyoshi T, Inagaki K, Nakamura E, Terasaka T, Takeda M, Ogura T, Iwasaki Y, Makino H
    • Journal Title

      Mol Cell Endocrinol

      Volume: 344 Pages: 41-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells.2011

    • Author(s)
      Naoko Tsukamoto, Fumio Otsuka, Tomoko Miyoshi, Kenichi Inagaki, Eri Nakamura, Tomohiro Terasaka, Masaya Takeda, Toshio Ogura, Yasumasa Iwasaki, Hirofumi Makino
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: vol.344 Issue: 1-2 Pages: 41-50

    • DOI

      10.1016/j.mce.2011.06.016

    • Related Report
      2011 Research-status Report
  • [Presentation] 筋強直性ジストロフィー合併原発性副甲状腺機能亢進症の一例2013

    • Author(s)
      塚本尚子
    • Organizer
      第21回臨床内分泌代謝Update
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2013-01-18
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] コルチコトロープ細胞におけるACTH分泌調節に及ぼすメラトニンとBMP-4の役割2012

    • Author(s)
      塚本尚子
    • Organizer
      第39回日本神経内分泌学会
    • Place of Presentation
      北九州国際会議場(YIA受賞)
    • Year and Date
      2012-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 下垂体コルチコトロープにおけるACTH分泌制御機構:GHRP/CRHとBMP-4の機能連関2012

    • Author(s)
      塚本尚子
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例2012

    • Author(s)
      塚本尚子
    • Organizer
      妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2012-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例2012

    • Author(s)
      塚本尚子
    • Organizer
      第21回 臨床内分泌代謝Update
    • Place of Presentation
      アクトシティ浜松
    • Related Report
      2011 Research-status Report
  • [Presentation] GHRP-2 による ACTH 分泌調節機序の検討と BMP-4 の関与2011

    • Author(s)
      塚本尚子
    • Organizer
      第38回日本神経内分泌学会
    • Place of Presentation
      都道府県会館
    • Year and Date
      2011-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel Interaction of Bone Morphogenetic Protein and Growth Hormone-Releasing Peptide in Regulating Adrenocorticotropin Production by Corticotrope Cells2011

    • Author(s)
      Naoko Tsukamoto
    • Organizer
      ENDO2011
    • Place of Presentation
      Boston Convention Center(USA)
    • Year and Date
      2011-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel Interaction of Bone Morphogenetic Protein and Growth Hormone-Releasing Peptide in Regulating Adrenocorticotropin Production by Corticotrope Cells2011

    • Author(s)
      Naoko Tsukamoto
    • Organizer
      ENDO 2011
    • Place of Presentation
      Boston Convention Center
    • Related Report
      2011 Research-status Report
  • [Presentation] GHRP-2によるACTH分泌調節機序の検討とBMP-4の関与2011

    • Author(s)
      塚本尚子
    • Organizer
      第38回日本神経内分泌学会
    • Place of Presentation
      都道府県会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 下垂体コルチコトロープにおけるACTH分泌制御機構:GHRP/CRHとBMP-4の機能連関

    • Author(s)
      塚本尚子
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] コルチコトロープ細胞におけるACTH分泌調節に及ぼすメラトニンとBMP-4の役割

    • Author(s)
      塚本尚子
    • Organizer
      第39回日本神経内分泌学会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] メラトニン受容体刺激によるACTH分泌抑制とその機序の検討

    • Author(s)
      塚本尚子
    • Organizer
      第86回日本内分泌学会学術集会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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