Roles of bone morphogenetic protein-6 inaldosterone regulation by adrenocortical cells

• Project/Area Number: 23791058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Okayama University
• Principal Investigator: TSUKAMOTO Naoko 岡山大学, 岡山大学病院, 助教 (90601302)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 内科学 / 内分泌 / 副腎 / ステロイド / 成長因子 / アルドステロン / BMP / エンドセリン

Research Abstract

In the present study, we examined the in vivo roleof BMP-6 in regulation of aldosterone by neutralizing endogenous BMP-6 in rats treated with immunization against BMP-6. It was suggested that endogenous BMP-6 is functionally linked to aldosterone synthesis in the adrenal cortex in vivo.

Research Products

• [Journal Article] Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling (2013)
  • Author(s): Matsumoto Y, Otsuka F, Takano-Narazaki M, Katsuyama T, Nakamura E, Tsukamoto N,Inagaki K, Sada KE, Makino H
  • Journal Title: Steroids Volume: 78 Pages: 513-520
  • Peer Reviewed
• [Journal Article] Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis (2013)
  • Author(s): Nakamura E, Otsuka F, Inagaki K, Tsukamoto N,Ogura-Ochi K, Miyoshi T, Toma K, Takeda M, Makino H
  • Journal Title: J Steroid Biochem Mol Biol Volume: 134 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling (2013)
  • Author(s): Yoshinori Matsumoto,Fumio Otsuka, Mariko Takano-Narazaki, Takayuki Katsuyama, Eri Nakamura, Naoko Tsukamoto, Kenichi Inagaki, Ken-ei Sada, Hirofumi Makino.
  • Journal Title: Steroids Volume: vol.78 Issue: 5 Pages: 513-520
  • DOI: 10.1016/j.steroids.2013.02.011
  • Peer Reviewed
• [Journal Article] An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland (2012)
  • Author(s): Matsumoto Y, Otsuka F, Inagaki K, Tsukamoto N,Takano-Narazaki M, Miyoshi T, Nakamura E, Ogura-Ochi K, Takeda M, Makino H
  • Journal Title: J Steroid Biochem Mol Biol Volume: 132 Pages: 8-14
  • Peer Reviewed
• [Journal Article] Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells (2012)
  • Author(s): Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H
  • Journal Title: Mol Cell Endocrinol Volume: 358 Pages: 18-26
  • Peer Reviewed
• [Journal Article] Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys (2012)
  • Author(s): Suzuki J, Otsuka F, Matsumoto Y, Inagaki K, Miyoshi T, Takeda M, Tsukamoto N,Nakamura E, Ogura K, Makino H
  • Journal Title: Hypertens Res Volume: 35 Pages: 312-7
  • NAID: 10030644434
  • Peer Reviewed
• [Journal Article] Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells (2012)
  • Author(s): Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Matsumoto Y, Ogura K, Tsukamoto N, Takeda M, Makino H
  • Journal Title: Endocrinology Volume: 153 Pages: 2012-2012
  • Peer Reviewed
• [Journal Article] BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells (2012)
  • Author(s): Otsuka F, Tsukamoto N, Miyoshi T, Iwasaki Y, Makino H
  • Journal Title: Mol Cell Endocrinol Volume: 349 Pages: 105-10
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-a (2012)
  • Author(s): Takano M, Otsuka F, Matsumoto Y, Inagaki K, Takeda M, Nakamura E, Tsukamoto N,Miyoshi T, Sada KE, Makino H
  • Journal Title: Mol Cell Endocrinol Volume: 348 Pages: 224-32
  • Peer Reviewed
• [Journal Article] Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LssT2 gonadotrope cells (2012)
  • Author(s): Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N,Makino H, Lawson MA
  • Journal Title: Mol Cell Endocrinol Volume: 348 Pages: 147-54
  • Peer Reviewed
• [Journal Article] Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis (2012)
  • Author(s): Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Kanako Ogura-Ochi, Tomoko Miyoshi, Kishio Toma, Masaya Takeda, Hirofumi Makino
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: vol.134 Pages: 67-74
  • DOI: 10.1016/j.jsbmb.2012.10.018
  • Peer Reviewed
• [Journal Article] An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland (2012)
  • Author(s): Yoshinori Matsumoto, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Mariko Takano-Narazaki, Tomoko Miyoshi, Eri Nakamura, Kanako Ogura-Ochi, Masaya Takeda, Hirofumi Makino
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: in press Issue: 1-2 Pages: 8-14
  • DOI: 10.1016/j.jsbmb.2012.04.004
  • Peer Reviewed
• [Journal Article] Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys. (2012)
  • Author(s): Jiro Suzuki, Fumio Otsuka, Yoshinori Matsumoto, Kenichi Inagaki, Tomoko Miyoshi, Masaya Takeda, Naoko Tsukamoto, Eri Nakamura, Kanako Ogura, Hirofumi Makino
  • Journal Title: Hypertension Research Volume: vol.35 Issue: 3 Pages: 312-317
  • DOI: 10.1038/hr.2011.186
  • NAID: 10030644434
  • Peer Reviewed
• [Journal Article] BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells. (2012)
  • Author(s): Fumio Otsuka, Naoko Tsukamoto, Tomoko Miyoshi, Yasumasa Iwasaki, Hirofumi Makino
  • Journal Title: Molecular and Cellular Endocrinology Volume: vol.349 Issue: 2 Pages: 105-110
  • DOI: 10.1016/j.mce.2011.10.017
• [Journal Article] Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells. (2012)
  • Author(s): Tomoko Miyoshi, Fumio Otsuka, Eri Nakamura, Kenichi Inagaki, Kanako Ogura-Ochi, Naoko Tsukamoto, Masaya Takeda, Hirofumi Makino
  • Journal Title: Molecular and Cellular Endocrinology Volume: in press
• [Journal Article] Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α. (2012)
  • Author(s): Mariko Takano, Fumio Otsuka, Yoshinori Matsumoto, Kenichi Inagaki, Masaya Takeda, Eri Nakamura, Naoko Tsukamoto, Tomoko Miyoshi, Ken-ei Sada, Hirofumi Makino
  • Journal Title: Molecular and Cellular Endocrinology Volume: vol.348 Issue: 1 Pages: 224-232
  • DOI: 10.1016/j.mce.2011.08.027
  • NAID: 120005232493
• [Journal Article] Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells. (2012)
  • Author(s): Masaya Takeda, Fumio Otsuka, Hiroaki Takahashi, Kenichi Inagaki, Tomoko Miyoshi, Naoko Tsukamoto, Hirofumi Makino, Mark A. Lawson
  • Journal Title: Molecular and Cellular Endocrinology Volume: vol.348 Issue: 1 Pages: 147-154
  • DOI: 10.1016/j.mce.2011.08.001
• [Journal Article] Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells. (2012)
  • Author(s): Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Tomoko Miyoshi, Yoshinori Matsumoto, Kanako Ogura, Naoko Tsukamoto, Masaya Takeda, Hirofumi Makino
  • Journal Title: Endocrinology Volume: vol.153 Issue: 1 Pages: 469-480
  • DOI: 10.1210/en.2011-1646
• [Journal Article] Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells (2011)
  • Author(s): Tsukamoto N, Otsuka F, Miyoshi T, Inagaki K, Nakamura E, Terasaka T, Takeda M, Ogura T, Iwasaki Y, Makino H
  • Journal Title: Mol Cell Endocrinol Volume: 344 Pages: 41-50
  • Peer Reviewed
• [Journal Article] Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells. (2011)
  • Author(s): Naoko Tsukamoto, Fumio Otsuka, Tomoko Miyoshi, Kenichi Inagaki, Eri Nakamura, Tomohiro Terasaka, Masaya Takeda, Toshio Ogura, Yasumasa Iwasaki, Hirofumi Makino
  • Journal Title: Molecular and Cellular Endocrinology Volume: vol.344 Issue: 1-2 Pages: 41-50
  • DOI: 10.1016/j.mce.2011.06.016
• [Presentation] 筋強直性ジストロフィー合併原発性副甲状腺機能亢進症の一例 (2013)
  • Author(s): 塚本尚子
  • Organizer: 第21回臨床内分泌代謝Update
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2013-01-18
• [Presentation] コルチコトロープ細胞におけるACTH分泌調節に及ぼすメラトニンとBMP-4の役割 (2012)
  • Author(s): 塚本尚子
  • Organizer: 第39回日本神経内分泌学会
  • Place of Presentation: 北九州国際会議場(YIA受賞)
  • Year and Date: 2012-09-28
• [Presentation] 下垂体コルチコトロープにおけるACTH分泌制御機構:GHRP/CRHとBMP-4の機能連関 (2012)
  • Author(s): 塚本尚子
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-04-21
• [Presentation] 妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例 (2012)
  • Author(s): 塚本尚子
  • Organizer: 妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2012-01-28
• [Presentation] 妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例 (2012)
  • Author(s): 塚本尚子
  • Organizer: 第21回 臨床内分泌代謝Update
  • Place of Presentation: アクトシティ浜松
• [Presentation] GHRP-2 による ACTH 分泌調節機序の検討と BMP-4 の関与 (2011)
  • Author(s): 塚本尚子
  • Organizer: 第38回日本神経内分泌学会
  • Place of Presentation: 都道府県会館
  • Year and Date: 2011-11-25
• [Presentation] A Novel Interaction of Bone Morphogenetic Protein and Growth Hormone-Releasing Peptide in Regulating Adrenocorticotropin Production by Corticotrope Cells (2011)
  • Author(s): Naoko Tsukamoto
  • Organizer: ENDO2011
  • Place of Presentation: Boston Convention Center(USA)
  • Year and Date: 2011-06-04
• [Presentation] A Novel Interaction of Bone Morphogenetic Protein and Growth Hormone-Releasing Peptide in Regulating Adrenocorticotropin Production by Corticotrope Cells (2011)
  • Author(s): Naoko Tsukamoto
  • Organizer: ENDO 2011
  • Place of Presentation: Boston Convention Center
• [Presentation] GHRP-2によるACTH分泌調節機序の検討とBMP-4の関与 (2011)
  • Author(s): 塚本尚子
  • Organizer: 第38回日本神経内分泌学会
  • Place of Presentation: 都道府県会館
• [Presentation] 下垂体コルチコトロープにおけるACTH分泌制御機構：GHRP/CRHとBMP-4の機能連関
  • Author(s): 塚本尚子
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] コルチコトロープ細胞におけるACTH分泌調節に及ぼすメラトニンとBMP-4の役割
  • Author(s): 塚本尚子
  • Organizer: 第39回日本神経内分泌学会
  • Place of Presentation: 北九州国際会議場
• [Presentation] メラトニン受容体刺激によるACTH分泌抑制とその機序の検討
  • Author(s): 塚本尚子
  • Organizer: 第86回日本内分泌学会学術集会
  • Place of Presentation: 仙台国際センター