| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We hypothesized that robust induction of a single arm of effector T cells, either Th1 or Th17, might be sufficient for inducing thyroiditis in NOD-H2h4 mice. To address this hypothesis, enhanced immune responses consisting of either Th1 or Th17 were induced by anti-CD25 antibody-mediated depletion of regulatory T cells in thyroiditis-resistant IL-17 knockout or IFN-receptor KO, respectively, NOD-H2h4 mice. Depletion of Treg in IL-17 KO mice elicited antithyroglobulin autoantibodies and thyroiditis. Our findings demonstrate that a robust Th1 immune response can by itselfinduce thyroiditis in otherwise thyroiditis-resistant IL-17 KO mice. Thus, unlike Th17 cells in IFN-RKO mice, Th1 cells enhanced by Treg depletion can be sustained and induce thyroiditis.
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