Analysis of the effector T cells in the pathogenesis of experimental autoimmune thyroid disease
Project/Area Number |
23791060
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Nagasaki University |
Principal Investigator |
HORIE Ichiro 長崎大学, 大学病院, 助教 (30457577)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 甲状腺 / 自己免疫 / IL-17 / IFN-gamma / Th17 / Th1 / バセドウ病 / 橋本病 / interleukin-17 / interferon-gamma / T helper type 1 (Th1) |
Research Abstract |
We hypothesized that robust induction of a single arm of effector T cells, either Th1 or Th17, might be sufficient for inducing thyroiditis in NOD-H2h4 mice. To address this hypothesis, enhanced immune responses consisting of either Th1 or Th17 were induced by anti-CD25 antibody-mediated depletion of regulatory T cells in thyroiditis-resistant IL-17 knockout or IFN-receptor KO, respectively, NOD-H2h4 mice. Depletion of Treg in IL-17 KO mice elicited antithyroglobulin autoantibodies and thyroiditis. Our findings demonstrate that a robust Th1 immune response can by itselfinduce thyroiditis in otherwise thyroiditis-resistant IL-17 KO mice. Thus, unlike Th17 cells in IFN-RKO mice, Th1 cells enhanced by Treg depletion can be sustained and induce thyroiditis.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.2013
Author(s)
Kuriya G, Uchida T, Akazawa S, Kobayashi M, Nakamura K, Satoh T, Horie I, Kawasaki E, Yamasaki H, Yu L, Iwakura Y, Sasaki H, Nagayama Y, Kawakami A, Abiru N.
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Journal Title
Diabetologia
Volume: 56
Issue: 8
Pages: 1773-1780
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of nonfunctioning pituitary carcinoma that responded to temozolomide treatment.2012
Author(s)
Morokuma H, Ando T, Hayashida T, Horie I, Inoshita N, Murata F, Ueki I, Nakamura K, Imaizumi M, Usa T, Kawakami A
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Journal Title
Case reports in endocrinology
Volume: 2012
Pages: 645914-645914
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI.2012
Author(s)
Murata F, Horie I, Ando T, Isomoto E, Hayashi H, Akazawa S, Ueki I, Nakamura K, Kobayashi M, Kuwahara H, Abiru N, Kawasaki E, Yamasaki H, Kawakami A.
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Journal Title
Endocr J
Volume: 59
Pages: 669-676
NAID
Related Report
Peer Reviewed
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[Presentation] 乳癌内分泌療法に伴う非アルコール性脂肪肝炎の臨床的検討2012
Author(s)
松崎 寿久, 高原 郁子, 堀江 一郎, 加藤 浩之, 森田 道, 松島 肇, 中島 弘治, 円城寺 昭人, 山口 淳三, 中尾 一彦, 島 正義
Organizer
第16回日本肝臓学会大会
Place of Presentation
神戸
Related Report
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[Presentation] 著明な高カルシウム血症を呈し後天性低カルシウム尿性高カルシウム血症(AHH)において発見された自己抗体の解析と治療2012
Author(s)
槙田 紀子, 安藤 隆雄, 佐藤 潤一郎, 間中 勝則, 村上 聡子, 堀江 一郎, 大石 篤郎, 矢嶋 由紀, 橋本 真紀子, 川上 純, 藤田 敏郎, 飯利 太朗
Organizer
第85回日本内分泌学会学術総会
Place of Presentation
名古屋
Related Report
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