| Project/Area Number |
23791068
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
SAKATA Mamiko (YANAGIMOTO Mamiko) 筑波大学, 筑波大学, 講師 (80451805)
|
|---|
| Research Collaborator |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 急性骨髄性白血病 / Notch / Hes1 / 腫瘍抑制 / サイトカイン受容体 / 腫瘍抑制因子 / MLL白血病 / レトロウイルス |
|---|
| Research Abstract |
We clarified the novel tumor suppressive roles of Hes1 in acute myeloid leukemia. Themechanism was downregulation of cytokine signaling by transcriptional repression of cytokine receptor by Hes1. Growth rate of Hes1-null leukemic cells was higher than that of control cells, which was abrogated by specific inhibitor for cytokine signaling. These data provide a novel insight into a target therapy for myeloid leukemia.
|
