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Analysis of Hes1 mediated development and maintenance of leukemic stem cells for myeloid leukemia

Research Project

Project/Area Number 23791068
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

SAKATA Mamiko (YANAGIMOTO Mamiko)  筑波大学, 筑波大学, 講師 (80451805)

Research Collaborator CHIBA Shigeru  筑波大学, 医学医療系, 教授 (60212049)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords急性骨髄性白血病 / Notch / Hes1 / 腫瘍抑制 / サイトカイン受容体 / 腫瘍抑制因子 / MLL白血病 / レトロウイルス
Research Abstract

We clarified the novel tumor suppressive roles of Hes1 in acute myeloid leukemia. Themechanism was downregulation of cytokine signaling by transcriptional repression of cytokine receptor by Hes1. Growth rate of Hes1-null leukemic cells was higher than that of control cells, which was abrogated by specific inhibitor for cytokine signaling. These data provide a novel insight into a target therapy for myeloid leukemia.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (75 results)

All 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 7 results) Presentation (52 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis.2012

    • Author(s)
      Yuhei Kamada
    • Journal Title

      Int J Hematol

      Volume: 96 Issue: 4 Pages: 492-500

    • DOI

      10.1007/s12185-012-1171-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early pathologic findings of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a proposal from a case.2012

    • Author(s)
      Nakamoto-Matsubara R
    • Journal Title

      Case Rep Hematol.

      Volume: 2012 Pages: 957612-957612

    • DOI

      10.1155/2012/957612

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 and Immune Function.2012

    • Author(s)
      Mamiko Sakata-Yanagimoto
    • Journal Title

      Curr Top Microbiol Immunol

      Volume: 360 Pages: 151-161

    • DOI

      10.1007/82_2012_235

    • ISBN
      9783642242939, 9783642242946
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] エピゲノム異常による造血器腫瘍の病態2012

    • Author(s)
      坂田 (柳元)麻実子, 千葉滋
    • Journal Title

      最新医学

      Volume: 67(10) Pages: 2413-2419

    • Related Report
      2012 Final Research Report
  • [Journal Article] 血液内科学 マスト細胞とNotchシグナル 粘膜免疫における役割2012

    • Author(s)
      坂田(柳元)麻実子
    • Journal Title

      医学のあゆみ

      Volume: 240 (7) Pages: 599-600

    • Related Report
      2012 Final Research Report
  • [Journal Article] 造血器腫瘍とNotchシグナル: 腫瘍活性化2ndHes1+/+ MLLAF9 N=72ndHes1-/- MLLAF9 N=7Hes1+/+ Hes-/-サイトカイン受容体の発現 および腫瘍抑制の二面的な役割2012

    • Author(s)
      加藤貴康, 坂田(柳元)麻実子, 千葉滋
    • Journal Title

      血液内科

      Volume: 64(6) Pages: 756-760

    • Related Report
      2012 Final Research Report
  • [Journal Article] Notchシグナルを標的にした新たな分子標的治療薬の開発2012

    • Author(s)
      坂田 (柳元)麻実子, 千葉滋
    • Journal Title

      血液内科

      Volume: 63(5) Pages: 568-573

    • NAID

      40019086799

    • Related Report
      2012 Final Research Report
  • [Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin2012

    • Author(s)
      Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
    • Journal Title

      Oncogene

      Volume: 31 Issue: 6 Pages: 787-79

    • DOI

      10.1038/onc.2011.265

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 1.エピゲノムとがん.2012

    • Author(s)
      坂田麻実子(柳元麻実子)
    • Journal Title

      実験医学

      Volume: 30 Pages: 2468-2473

    • Related Report
      2012 Annual Research Report
  • [Journal Article] エピゲノム異常による造血器腫瘍の病態.2012

    • Author(s)
      坂田麻実子(柳元麻実子)
    • Journal Title

      最新医学

      Volume: 67 Pages: 2413-2419

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 血液内科学 マスト細胞とNotchシグナル 粘膜免疫における役割.2012

    • Author(s)
      医学のあゆみ
    • Journal Title

      医学のあゆみ

      Volume: 240 Pages: 599-600

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 造血器腫瘍とNotchシグナル: 腫瘍活性化および腫瘍抑制の二面的な役割.2012

    • Author(s)
      加藤貴康
    • Journal Title

      血液内科

      Volume: 64 Pages: 756-760

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Notchシグナルを標的にした新たな分子標的治療薬の開発.2012

    • Author(s)
      坂田麻実子(柳元麻実子)
    • Journal Title

      血液内科

      Volume: 63 Pages: 5680573-5680573

    • Related Report
      2012 Annual Research Report
  • [Journal Article] マスト細胞とNotchシグナル-腸管免疫における役割2012

    • Author(s)
      坂田(柳元)麻実子
    • Journal Title

      医学のあゆみ

      Volume: 第240巻第7号 Pages: 599-600

    • Related Report
      2011 Research-status Report
  • [Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis2011

    • Author(s)
      Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S
    • Journal Title

      J Clin Exp Hematop

      Volume: 51(2) Pages: 109-114

    • NAID

      10030207641

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia2011

    • Author(s)
      Kenichi Yoshida
    • Journal Title

      Nature

      Volume: 478 Issue: 7367 Pages: 64-69

    • DOI

      10.1038/nature10496

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腸管免疫とNotch22011

    • Author(s)
      坂田 (柳元)麻実子
    • Journal Title

      血液内科

      Volume: 63(4) Pages: 488-492

    • Related Report
      2012 Final Research Report
  • [Journal Article] 一般内科医がみる血液疾患 血液専門医との効率的な連携のために 血液に影響を及ぼすさまざまな背景 妊娠と血液疾患 妊娠に伴う血液学的な変化2011

    • Author(s)
      坂田 (柳元)麻実子
    • Journal Title

      medicina

      Volume: 48(10) Pages: 1745-1747

    • Related Report
      2012 Final Research Report
  • [Journal Article] Treatment Outcome of Adult Burkitt Lymphoma in Japanese Patients with Modified LMB Protocol : A Single Center Retrospective Analysis2011

    • Author(s)
      Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 51 Issue: 2 Pages: 109-114

    • DOI

      10.3960/jslrt.51.109

    • NAID

      10030207641

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Notchシグナルを標的とした新たな分子標的治療薬の開発2011

    • Author(s)
      坂田(柳元) 麻実子
    • Journal Title

      血液内科

      Volume: 第63巻第5号 Pages: 568-573

    • Related Report
      2011 Research-status Report
  • [Journal Article] 腸管免疫とNotch22011

    • Author(s)
      坂田(柳元)麻実子
    • Journal Title

      血液内科

      Volume: 第63巻第4号 Pages: 488-492

    • Related Report
      2011 Research-status Report
  • [Journal Article] 妊娠と血液疾患-妊娠に伴う血液学的な変化2011

    • Author(s)
      坂田(柳元)麻実子
    • Journal Title

      medicina

      Volume: 第48巻第10号 Pages: 1745-1747

    • Related Report
      2011 Research-status Report
  • [Presentation] Notch-Hes1 signaling: double-edged swords for myeloid leukemia.2012

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第2回つくばがん研究会
    • Place of Presentation
      つくば
    • Year and Date
      2012-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription factor Hes1 functions as a tumor suppressor in MLL-associated acute leukemia2012

    • Author(s)
      Takayasu Kato
    • Organizer
      The American Society of Hematology 54th Annual meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduced TET2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice2012

    • Author(s)
      Hideharu Muto
    • Organizer
      The American Society of Hematology 54th Annual meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA hydroxymethylation in hematologic malignancies2012

    • Author(s)
      Mamiko Sakata-Yanagimoto
    • Organizer
      第74回日本血液学会学術集会, シンポジウム(Myeloid malignancies in a New Era of Molecularly Targeted Therapy)
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduced TET2 expression confers enhanced competitive repopulation capacity on HSCs2012

    • Author(s)
      Hideharo Muto
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcripation factor Hes1 functions as a tumor suppressor in MLL-associated acute leukemias2012

    • Author(s)
      Takayasu Kato
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] TET2 regulates erythropoiesis from human cord blood progenitors2012

    • Author(s)
      Terukazu Enami
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical study of nilotinib in CML-CP patients with imatinib resistance or intolerance: TSSG study2012

    • Author(s)
      Koiti Inokuchi
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Spectrum of gene mutations in myelodysplastic syndromes revealed by whole-exome sequencing2012

    • Author(s)
      Kenichi Yoshida
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel Recurrent Mutations of multiple components of cohesion complex in myeloid neoplasms2012

    • Author(s)
      Ayano Kon
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of a new class of megakaryocyte progenitors in the mouse bone marrow2012

    • Author(s)
      Kenji Matsushita
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Recombinant thrombomodulin for DIC with hematologic malignancy-a single-center re-evaluation2012

    • Author(s)
      Naoki Kurita
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Attempting a timeline for survival disadvantage in the recipients who have delayed engrafment2012

    • Author(s)
      Yuichi Hasegawa
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Control of perisurgical hemolysis by temporal induction of eculizumab in a patient with PNH2012

    • Author(s)
      Naoki Kurita
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Efficacy and safety of rabbit anti-thymocyte globulin for aplastic anemia in two different doses2012

    • Author(s)
      Tatsuhiro Sakamoto
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription factor Hes1 funcutions as a tumor suppressor in MLL-associated acute leukemias2012

    • Author(s)
      Takayasu Kato
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Rare mutations of splicing machinery in MDS with complex karyotype2012

    • Author(s)
      Yasunobu Nagata
    • Organizer
      17th Congress of EHA
    • Place of Presentation
      Amsterdam, Nederland
    • Related Report
      2012 Final Research Report
  • [Presentation] Recurrent mutations of multiple components of cohesin complex in myeloid neoplasms2012

    • Author(s)
      Ayano Kon
    • Organizer
      17th Congress of EHA
    • Place of Presentation
      Amsterdam, Nederland
    • Related Report
      2012 Final Research Report
  • [Presentation] Spectrum of gene mutations and their intratumoral structure in myelodysplasia revealed by high-throughput sequencing2012

    • Author(s)
      Kenichi Yoshida
    • Organizer
      17th Congress of EHA
    • Place of Presentation
      Amsterdam, Nederland
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of TET2-mediated DNA oxygenation in hematopoiesis2012

    • Author(s)
      Shigeru Chiba
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Final Research Report
  • [Presentation] Impaired Tet2 function leads to enlargement of hematopoietic stem cell compartment and competitive repopulation capacity2012

    • Author(s)
      Hideharu Muto
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of monolineage megakaryocyte progenitor cells through a previously unidentified differentiation pathway2012

    • Author(s)
      Hidekazu Nishikii
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Unbalanced Genome Copy Number Abnormalities in Patients with Multiple Myeloma.2012

    • Author(s)
      Yuhei Kamada
    • Organizer
      第3回JSH国際シンポジウム
    • Place of Presentation
      川越
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Hes1と骨髄性白血病2012

    • Author(s)
      加藤貴康
    • Organizer
      第16回造血器腫瘍研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription factor Hes1 functions as a tumor suppressor in MLL-associated acute leukemia.2012

    • Author(s)
      Takayasu Kato
    • Organizer
      The American Society of Hematology 54th Annual meeting
    • Place of Presentation
      Atlanta (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reduced TET2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice.2012

    • Author(s)
      Hideharu Muto
    • Organizer
      The American Society of Hematology 54th Annual meeting
    • Place of Presentation
      Atlanta (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA hydroxymethylation in hematologic malignancies.2012

    • Author(s)
      Mamiko Sakata-Yanagimoto
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Reduced TET2 expression confers enhanced competitive repopulation capacity on HSCs.2012

    • Author(s)
      Hideharo Muto
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transcripation factor Hes1 functions as a tumor suppressor in MLL-associated acute leukemias.2012

    • Author(s)
      Takayasu Kato
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] TET2 regulates erythropoiesis from human cord blood progenitors.2012

    • Author(s)
      Terukazu Enami
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of a new class of megakaryocyte progenitors in the mouse bone marrow.2012

    • Author(s)
      Kenji Matsushita
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transcription factor Hes1 funcutions as a tumor suppressor in MLL-associated acute leukemias.2012

    • Author(s)
      Takayasu Kato
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of TET2-mediated DNA oxygenation in hematopoiesis.2012

    • Author(s)
      Shigeru Chiba
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impaired Tet2 function leads to enlargement of hematopoietic stem cell compartment and competitive repopulation capacity.2012

    • Author(s)
      Hideharu Muto
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of monolineage megakaryocyte progenitor cells through a previously unidentified differentiation pathway.2012

    • Author(s)
      Hidekazu Nishikii
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hes1と骨髄性白血病2012

    • Author(s)
      加藤貴康
    • Organizer
      第16回造血器腫瘍研究会
    • Place of Presentation
      国立がんセンター研究所(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of 5-hydroxymethylcytosine in blood cells from normal subjects and MDS/leukemia patients2011

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第2回JSH国際シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2011-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Mutational Spectrum Analysis of Interesting Correlation and Interrelationship Between RNA Splicing Pathway and Commonly Targeted Genes in Myelodysplastic Syndrome2011

    • Author(s)
      Yasunobu Nagata
    • Organizer
      The American Society of Hematology 53rd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia.2011

    • Author(s)
      Kenichi Yoshida
    • Organizer
      The American Society of Hematology 53rd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 多発性骨髄腫におけるSNPアレイを用いた網羅的ゲノム異常の解析2011

    • Author(s)
      鎌田勇平
    • Organizer
      第73回日本血液学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト造血細胞および白血病細胞におけるハイドロキシメチルシトシンの評価.2011

    • Author(s)
      坂田 (柳元)麻実子
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄球系前駆細胞の不死化におけるHes-1の下流メカニズムの解析2011

    • Author(s)
      三宅康行
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生不良性貧血に対するATG 療法の有効性と安全性に関する検討2011

    • Author(s)
      坂本竜弘
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 多発性骨髄腫におけるSNPアレイを用いた網羅的ゲノム異常の解析2011

    • Author(s)
      鎌田勇平
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of 5-hydroxymethylcytosine in blood cells from normal subjects and patients with hematologic malignancies2011

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of 5-hydroxymethylcytosine in human blood cells and leukemic cells.2011

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of downstream target of Hes-1 in immortalization of myeloid progenitors.2011

    • Author(s)
      三宅康行
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of whole genome copy number abnormalities in multiple myeloma patients.2011

    • Author(s)
      鎌田勇平
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of whole genome copy number abnormalities in multiple myeloma patients.2011

    • Author(s)
      鎌田勇平
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of 5-hydroxymethylcytosine in blood cells from normal subjects and patients with hematologic malignancies.2011

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      泉ガーデンギャラリー(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of 5-hydroxymethylcytosine in blood cells from normal subjects and MDS/leukemia patients.2011

    • Author(s)
      坂田(柳元)麻実子
    • Organizer
      第2回JSH国際シンポジウム
    • Place of Presentation
      長崎ブリックホール(長崎市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Notch-Hes1 signaling: double-edged swords for myeloid leukemia.

    • Author(s)
      坂田麻実子(柳元)
    • Organizer
      第2回つくばがん研究会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学 別冊「がんと代謝」2012

    • Author(s)
      坂田 (柳元)麻実子, 千葉滋
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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