Analysis of Hes1 mediated development and maintenance of leukemic stem cells for myeloid leukemia
| Project/Area Number |
23791068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SAKATA Mamiko (YANAGIMOTO Mamiko) 筑波大学, 筑波大学, 講師 (80451805)
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| Research Collaborator |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 急性骨髄性白血病 / Notch / Hes1 / 腫瘍抑制 / サイトカイン受容体 / 腫瘍抑制因子 / MLL白血病 / レトロウイルス |
|---|
| Research Abstract |
We clarified the novel tumor suppressive roles of Hes1 in acute myeloid leukemia. Themechanism was downregulation of cytokine signaling by transcriptional repression of cytokine receptor by Hes1. Growth rate of Hes1-null leukemic cells was higher than that of control cells, which was abrogated by specific inhibitor for cytokine signaling. These data provide a novel insight into a target therapy for myeloid leukemia.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin2012
Author(s)
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
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Journal Title
Oncogene. 9
Volume: 31
Pages: 787-79
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis2011
Author(s)
Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S
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Journal Title
J Clin Exp Hematop
Volume: 51(2)
Pages: 109-114
NAID
Related Report
Peer Reviewed
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[Journal Article] Treatment Outcome of Adult Burkitt Lymphoma in Japanese Patients with Modified LMB Protocol : A Single Center Retrospective Analysis2011
Author(s)
Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
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Journal Title
J Clin Exp Hematopathol
Volume: 51
Issue: 2
Pages: 109-114
DOI
NAID
Related Report
Peer Reviewed
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