Demonstration of Hes-1oscillation in progenitors and analysis of its effect on differentiation in hematopoiesis
| Project/Area Number |
23791070
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 血液腫瘍学 / Hes-1 / 白血病 / 発現振動 / Hes1 / oscillation / leukemia / hematopoiesis |
|---|
| Research Abstract |
We demonstrated ultradian oscillation of Hes-1 expression in single hematopoietic progenitor cells separated from murine fetal liver. Hematopoietic progenitors introduced with MLL-AF9 fusion gene cause leukemia in in vivo model. When progenitors derived from Hes-1 knockout mice were used, the Hes-1-knockout cells with MLL-AF9 caused earlier death than wild-type cells, which indicated that Hes-1 works as tumor suppressor gene in MLL-AF9 leukemia.
|
Report
(3 results)
Research Products
(4 results)
