Analysis of the function of KLF5 in blood cells and elucidation of its underlying molecular mechanism which leads to clinical application

Research Project

Project/Area Number	23791072
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hematology
Research Institution	The University of Tokyo
Principal Investigator	MATSUMURA Takayoshi 東京大学, 医学部附属病院, 助教 (80436485)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	血球細胞 / 巨核球 / 血小板 / 血管新生 / 転写因子 / 血液内科学 / KLF5
Research Abstract	With a broad analysis of the function of KLF5 in blood cells, I found that KLF5 is critical especially to normal functions of platelets. Platelet lineage-specific Klf5-knockout mice showed impaired in vivo thrombus formation and angiogenesis activity, and I investigated the underlying molecular mechanisms. Our results can lead to future therapeutic interventions for various cardiovascular and cancer diseases

Report

(3 results)