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Regulations of hematopoietic stem cell system by the control ofintracellular ATP

Research Project

Project/Area Number 23791076
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKanazawa University

Principal Investigator

TADOKORO Yuko  金沢大学, がん進展制御研究所, 助教 (00447343)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords幹細胞 / 細胞内ATP
Research Abstract

Many tissue specific stem cells stay dormant. Therefore, the regulation of intracellular ATP is important for the control of the longevity or behaviors of stem cells. The LKB1-AMPK signaling functions as an intracellular energy sensor. To examine the role of LKB1 or AMPK in the regulatory system of hematopoietic stem cell, I analyzed LKB1- or AMPK-deficient hematopoietic stem cells. Our data demonstrated that LKB1 and AMPK contributed to the maintenance of hematopoietic stem cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Nucleostemin in injury-induced liver regeneration.2012

    • Author(s)
      Shugo. H
    • Journal Title

      Stem cells Dev.

      Volume: 21 Issue: 16 Pages: 3044-3054

    • DOI

      10.1089/scd.2011.0725

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] mTORC1is essential for leukemia propagation but not stem cell self-renewal.2012

    • Author(s)
      Hoshii. T
    • Journal Title

      J Clin Invest.

      Volume: 122 Issue: 6 Pages: 2114-2129

    • DOI

      10.1172/jci62279

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] mTORC1 is essential for leukemia-propagation but not stem cell self-renewal2012

    • Author(s)
      Takayuki Hoshii
    • Journal Title

      The Journal of Clinical Investigation

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular pathology of tumor-initiating cells : lessons from Philadelphia chromosome-positive leukemia2011

    • Author(s)
      Naka K, Hoshii T, Tadokoro Y, Hirao A.
    • Journal Title

      Pathol Int

      Volume: 61 Issue: 9 Pages: 501-8

    • DOI

      10.1111/j.1440-1827.2011.02688.x

    • NAID

      10031185122

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] A competitive advantage ofhematopoietic stem cells in the bone marrow controlled by Spred-12012

    • Author(s)
      Yuko Tadokoro
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Final Research Report
  • [Presentation] A competitive advantage ofhematopoietic stem cells in the bone marrow controlled by Spred-12012

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 10thStem Cell Research Symposium
    • Place of Presentation
      兵庫県立淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] A competitive advantage of hematopoietic stem cells in the bone marrow microenvironment controlled by Spred-12012

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 10th Stem Cell Research Symposium
    • Place of Presentation
      兵庫県立淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A competitive advantage of hematopoietic stem cells in the bone marrow controlled by Spred-12012

    • Author(s)
      Yuko Tadokoro
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011

    • Author(s)
      Yuko Tadokoro
    • Organizer
      日本分子生物学会 第11回春季シンポジウム
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2011-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 6thInternational Symposium of Institute Network
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 9thStem Cell Research Symposium
    • Place of Presentation
      泉ガーデンギャラリー(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 9th Stem Cell Research Symposium
    • Place of Presentation
      泉ガーデンギャラリー(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011

    • Author(s)
      Yuko Tadokoro
    • Organizer
      The 6th International Symposium of Institute Network
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-1

    • Author(s)
      Yuko Tadokoro
    • Organizer
      日本分子生物学会 第11回春季シンポジウム
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Related Report
      2011 Research-status Report
  • [Book] 再生医療 "組織幹細胞システムにおける幹細胞ニッチ"2011

    • Author(s)
      田所 優子, 平尾 敦
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 再生医療 "組織幹細胞システムにおける幹細胞ニッチ"2011

    • Author(s)
      田所 優子
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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