Late effect and quality of life after hematopoietic stem cell transplantation

• Project/Area Number: 23791077
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: ATSUTA Yoshiko 名古屋大学, 医学系研究科, 寄附講座講師 (50432274)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 造血幹細胞移植 / 晩期障害 / 晩期死亡 / QOL

Research Abstract

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Research Products

• [Journal Article] A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation (2013)
  • Author(s): Nakasone H, Kanda J, Yano S, Atsuta Y, Ago H, Fukuda T, Kakihana K, Adachi T, Yujiri T, Taniguchi S, Taguchi J, Morishima Y, Nagamura T, Sakamaki H, Mori T, Murata M.
  • Journal Title: Transpl Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia (2013)
  • Author(s): Atsuta Y, Kanda J, Takanashi M, Morishima Y, Taniguchi S, Takahashi S, Ogawa H, Ohashi K, Ohno Y, Onishi Y, Aotsuka N, Nagamura-Inoue T, Kato K, Kanda Y.
  • Journal Title: Haematologica. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Unrelated cord blood transplantation vs related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction (2013)
  • Author(s): Kanda J, Ichinohe T, Kato S, Uchida N, Terakura S, Fukuda T, Hidaka M, Ueda Y, Kondo T, Taniguchi S, Takahashi S, Nagamura-Inoue T, Tanaka J, Atsuta Y, Miyamura K, Kanda Y.
  • Journal Title: Leukemia Volume: 27 Pages: 286-94
  • Peer Reviewed
• [Journal Article] A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation. (2013)
  • Author(s): Nakasone H, Kanda J, Yano S, Atsuta Y, Ago H, Fukuda T, Kakihana K, Adachi T, Yujiri T, Taniguchi S, Taguchi J, Morishima Y, Nagamura T, Sakamaki H, Mori T, Murata M
  • Journal Title: Transpl Int. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia. (2013)
  • Author(s): Atsuta Y, Kanda J, Takanashi M, Morishima Y, Taniguchi S, Takahashi S, Ogawa H, Ohashi K, Ohno Y, Onishi Y, Aotsuka N, Nagamura-Inoue T, Kato K, Kanda Y.
  • Journal Title: Haematologica. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Unrelated cord blood transplantation vs related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction (2013)
  • Author(s): Kanda J, Ichinohe T, Kato S, Uchida N, Terakura S, et al.
  • Journal Title: Leukemia Volume: 27 Issue: 2 Pages: 286-294
  • DOI: 10.1038/leu.2012.203
  • Peer Reviewed
• [Journal Article] Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T -cell leukemia: a retrospective cohort study (2012)
  • Author(s): Kanda J, Hishizawa M, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y, Tanosaki R, Kawano F, Miyazaki Y, Masuda M, Nagafuji K, Hara M, Takanashi M, Kai S, Atsuta Y, Suzuki R, Kawase T, Matsuo K, Nagamura-Inoue T, Kato S, Sakamaki H, Morishima Y, Okamura J, Ichinohe T, Uchiyama T.
  • Journal Title: Blood Volume: 119 Pages: 2141-8
  • Peer Reviewed
• [Journal Article] Center for International Blood and Marrow Transplant Research (CIBMTR); American Society for Blood and Marrow Transplantation (ASBMT); (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A;
  • Journal Title: European Group for Blood and Marrow Transplantation (EBMT); Volume: 18 Pages: 348-71
  • Peer Reviewed
• [Journal Article] Asia-Pacific Blood and Marrow Transplantation Group (APBMT); (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A;
  • Journal Title: Bone Marrow Transplant Society of Australia and New Zealand (BMTSANZ); Volume: 47 Pages: 337-41
  • Peer Reviewed
• [Journal Article] East Mediterranean Blood and Marrow Transplantation Group (EMBMT) (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A;
  • Journal Title: Sociedade Brasileira de Transplante de Medula Ossea (SBTMO) Volume: 5 Pages: 1-30
  • Peer Reviewed
• [Journal Article] for the Japan Marrow Donor Program and the Japan Cord Blood Bank Network: Comparison of unrelated cord blood transplantation and HLA mismatched unrelated bone marrow transplantation for adults with leukemia (2012)
  • Author(s): Atsuta Y., Morishima Y., Suzuki R., Nagamura-Inoue T., Taniguchi S., Takahashi S., Kai S., Sakamaki H., Kouzai Y., Kobayashi N., Fukuda T., Azuma H., Takanashi M., Mori T., Tsuchida M., Kawase T., Kawa K., Kodera Y. and Kato S.
  • Journal Title: Biol Blood Marrow Transplant Volume: 18 Pages: 780-787
  • Peer Reviewed
• [Journal Article] Related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction and HLA 8/8-allele-matched unrelated transplantation: A nationwide retrospective study. (2012)
  • Author(s): Kanda J., Saji H., Fukuda T., Kobayashi T., Miyamura K., Eto T., Kurokawa M., Kanamori H., Mori T., Hidaka M., Iwato K., Yoshida T., Sakamaki H., Tanaka J., Kawa K., Morishima Y., Suzuki R., Atsuta Y. and Kanda Y.
  • Journal Title: Blood Volume: 119 Pages: 2409-16
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis (2012)
  • Author(s): Ishiyama K, Takami A, Kanda Y, Nakao S, Hidaka M, Maeda T, Naoe T, Taniguchi S, Kawa K, Nagamura T, Atsuta Y, Sakamaki H
  • Journal Title: Leukemia Volume: 26 Pages: 461-4
  • Peer Reviewed
• [Journal Article] Recommended Screening and Preventive Practices for Long-Term Survivors after Hematopoietic Cell Transplantation. (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A
  • Journal Title: Hematol Oncol Stem Cell Ther. Volume: 5 Issue: 1 Pages: 1-30
  • DOI: 10.5144/1658-3876.2012.1
  • NAID: 130004501865
  • Peer Reviewed
• [Journal Article] Recommended Screening and Preventive Practices for Long-Term Survivors after Hematopoietic Cell Transplantation. (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A
  • Journal Title: Bone Marrow Transplant Volume: 47 Issue: 3 Pages: 337-341
  • DOI: 10.1038/bmt.2012.5
  • NAID: 130004501865
  • Peer Reviewed
• [Journal Article] Recommended Screening and Preventive Practices for Long-Term Survivors after Hematopoietic Cell Transplantation. (2012)
  • Author(s): Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A
  • Journal Title: Biol Blood Marrow Transplant. Volume: 18 Issue: 3 Pages: 348-371
  • DOI: 10.1016/j.bbmt.2011.12.519
  • NAID: 130004501865
  • Peer Reviewed
• [Journal Article] Comparison of unrelated cord blood transplantation and HLA mismatched unrelated bone marrow transplantation for adults with leukemia (2012)
  • Author(s): Atsuta Y, et al
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: (In press) Issue: 5 Pages: 780-787
  • DOI: 10.1016/j.bbmt.2011.10.008
  • Peer Reviewed
• [Journal Article] Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia : a retrospective cohort study (2012)
  • Author(s): Junya Kanda
  • Journal Title: Blood Volume: 119 Issue: 9 Pages: 2141-2148
  • DOI: 10.1182/blood-2011-07-368233
  • Peer Reviewed
• [Journal Article] Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation : a nationwide retrospective study (2012)
  • Author(s): Junya Kanda
  • Journal Title: Blood Volume: 119 Issue: 10 Pages: 2409-2416
  • DOI: 10.1182/blood-2011-08-372573
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6 ; 9)(p23 ; q34) dramatically improves the patient prognosis : a matched-pair analysis (2012)
  • Author(s): Ishiyama K, Takami A, (他10名)
  • Journal Title: Leukemia Volume: (in press) Issue: 3 Pages: 461-464
  • DOI: 10.1038/leu.2011.229
  • Peer Reviewed
• [Journal Article] Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia (2011)
  • Author(s): Shigematsu A, et al
  • Journal Title: International Journal of Hematology Volume: 94(5) Issue: 5 Pages: 463-471
  • DOI: 10.1007/s12185-011-0944-2
  • Peer Reviewed
• [Journal Article] Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan (2011)
  • Author(s): Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S.
  • Journal Title: Br J Haematol Volume: 154 Issue: 3 Pages: 363-372
  • DOI: 10.1111/j.1365-2141.2011.08735.x
  • Peer Reviewed
• [Journal Article] A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hemato poietic malignancies (2011)
  • Author(s): Terakura S, et al
  • Journal Title: Annals of Oncology Volume: 22(8) Issue: 8 Pages: 1865-1871
  • DOI: 10.1093/annonc/mdq673
  • Peer Reviewed
• [Journal Article] A decision analysis of allogeneic hematopoietic stem cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor (2011)
  • Author(s): Kako S, Morita S, Sakamaki H, Ogawa H, Fukuda T, Takahashi S, Kanamori H, Onizuka M, Iwato K, Suzuki R, Atsuta Y, et al.
  • Journal Title: Leukemia Volume: 25 Issue: 2 Pages: 259-265
  • DOI: 10.1038/leu.2010.260
  • Peer Reviewed
• [Journal Article] Use of mycophenolate mofetil in patients received allogeneic hematopoietic stem cell transplantation in Japan (2011)
  • Author(s): Iida M, Takami A
  • Journal Title: Int J Hematol Volume: 93 Issue: 4 Pages: 523-31
  • DOI: 10.1007/s12185-011-0817-8
  • NAID: 10029534696
  • Peer Reviewed
• [Journal Article] Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia (2011)
  • Author(s): Mizuta S, Matsuo K, Yagasaki F, Yujiri T, Hatta Y, Kimura Y, Ueda Y, Kanamori H, Usui N, Akiyama H, Miyazaki Y, Ohtake S, Atsuta Y, Sakamaki H, Kawa K, Morishima Y, Ohnishi K, Naoe T, Ohno R
  • Journal Title: Leukemia Volume: 25 Issue: 1 Pages: 41-47
  • DOI: 10.1038/leu.2010.228
  • Peer Reviewed
• [Presentation] 非血縁者間臍帯血と HLA 不一致非血縁者間骨髄移植における移植成績の比較 (2013)
  • Author(s): 熱田由子
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: 石川県立音楽堂
• [Presentation] Current Status of APBMT Outcome Registry (2012)
  • Author(s): Yoshiko Atsuta
  • Organizer: The 17th Annual Meeting of the Asia-Pacific Blood and Marrow Transplantation Group;
  • Place of Presentation: Hyderabad, India
• [Presentation] Late complication and mortality after allogeneic HSCT (2012)
  • Author(s): Yoshiko Atsuta
  • Organizer: Asian Workshop for Hematopoietic Stem Cell Transplantation
  • Place of Presentation: Aso, Japan
• [Presentation] 臨床研究論文の読み方-統計を中心に- (2012)
  • Author(s): 熱田由子
  • Organizer: 第74回日本血液学会学術集会日本血液学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Late mortality and cause of death among long survivors after allogeneic stem cell transplantation (2012)
  • Author(s): Yoshiko Atsuta, Hideki Nakasone, Saiko Krosawa, Kumi Oshima, Rika sakai, Kazuteru Ohashi, Takahiro Fukuda, Satoshi Takahasi, Takehiko Rori, Yassuo Morisima, Koji Kato, Hiromasa Yabe, Hisashi Sakamaki, Shuichi Taniguchi
  • Organizer: The 74nd Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto,Japan
• [Presentation] Stem cell source selection for allogeneic hematopoietic stem cell transplantation from unrelated donors; focused on comparison between cord blood and bone marrow (2011)
  • Author(s): 熱田由子
  • Organizer: 第73回日本血液学会総会、JSH-EHA Joint Symposium（招待講演）(招待講演)
  • Place of Presentation: 名古屋国際会議場（名古屋）
• [Presentation] 臨床研究論文の読み方―統計を中心に―
  • Author(s): 熱田由子
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都府国際会議場
  • Invited
• [Presentation] Late mortality and cause of death among long survivors after allogeneic stem cell transplantation.
  • Author(s): Yoshiko Atsuta, Hideki Nakasone, Saiko Krosawa, Kumi Oshima, et al.
  • Organizer: The 74nd Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 京都府国際会議場
• [Presentation] 非血縁者間臍帯血とHLA不一致非血縁者間骨髄移植における移植成績の比較
  • Author(s): 熱田由子
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: 石川県立音楽堂
  • Invited
• [Presentation] Current Status of APBMT Outcome Registry
  • Author(s): Yoshiko Atsuta
  • Organizer: The 17th Annual Meeting of the Asia-Pacific Blood and Marrow Transplantation Group
  • Place of Presentation: Hyderabad, India
  • Invited
• [Book] 同種造血幹細胞移植後の二次発がんに対するスクリーニング (2012)
  • Author(s): 熱田由子
  • Publisher: 中外医学社
• [Book] 造血幹細胞移植領域の統計 みんなに役立つ造血幹細胞移植の基礎と臨床 (2012)
  • Author(s): 熱田由子
  • Publisher: 医薬ジャーナル社
• [Book] 同種造血幹細胞移植後の二次発がんに対するスクリーニング 2013-2014 EBM 血液疾患の治療 (2012)
  • Author(s): 熱田由子
  • Publisher: 中外医学社
• [Book] 造血幹細胞移植領域の統計 みんなに役立つ造血幹細胞移植の基礎と臨床 改訂版 (2012)
  • Author(s): 熱田由子
  • Publisher: 医薬ジャーナル社
• [Book] 統計学を含む臨床研究. 血液専門医テキスト (2011)
  • Author(s): 熱田由子
  • Total Pages: 556
  • Publisher: 日本血液学会編集 南江堂