Clarification of immune regulation system by lymphocyte activated marker TFL

• Project/Area Number: 23791081
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: MINAGAWA Kentaro 神戸大学, 医学部附属病院, 医員 (80432574)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 血液免疫学 / TFL / Zc3h12d

Research Abstract

We recently identified a novel gene, transformed follicular lymphoma (TFL). We established TFL KO mice. We generated an experimental model of autoimmune encephalitis using TFL KO mice. Brain inflammation in KO mice showing paralysis prolonged compared with wild mice. The lymphocyte subsets infiltrating inthe brain were significantly shifted to Th17+.

Research Products

• [Journal Article] The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages (2012)
  • Author(s): Huang S, Qi D, Liang J, Miao R, Minagawa K, Quinn T, Matsui T, Fan D, Liu J, Fu M.
  • Journal Title: Cell Signal Volume: 24巻 Issue: 2 Pages: 569-76
  • DOI: 10.1016/j.cellsig.2011.10.011
  • Peer Reviewed
• [Presentation] A novel zinc finger protein TFL suppresses IL-17 dependent T-cell-mediated autoimmune disease (2012)
  • Author(s): 皆川 健太郎
  • Organizer: 第74回日本血液学会学術集会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] A novel zinc finger protein TFL suppresses IL-17 dependent T-cell-mediated autoimmune disease (2012)
  • Author(s): 皆川 健太郎
  • Organizer: 第７４回日本血液学会学術総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] A novel activated lymphocyte marker TFL is highly expressed in follicular lymphoma but less in DLBCL (2011)
  • Author(s): 皆川 健太郎
  • Organizer: 第73回日本血液学会学術集会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] A novel activated lymphocyte marker TFL is highly expressed in follicular lymphoma but less in DLBCL (2011)
  • Author(s): Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano1, Mari Sato, Akiko Sada, Yoshio Katayama, Junichi Tamaru, Masahiro Kizaki, Toshimitsu Matsui
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/ketueki/introduction.html
• [Remarks] 神戸大学 大学院 医学研究科 血液内科 ホームページ
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/ketueki/research2.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/ketueki/research.html