Analysis of acute myeloid leukemia development mechanisms induced by MOZ/MLL fusion genes

• Project/Area Number: 23791094
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: National Cancer Center Japan
• Principal Investigator: KATSUMOTO Takuo 独立行政法人国立がん研究センター, 研究所, 研究員 (50469970)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 発現制御 / 癌 / 幹細胞 / 発生・分化 / 急性骨髄性白血病 / 融合遺伝子 / 遺伝子発現制御

Research Abstract

In this study, I mainly analyzed roles of endogenous MOZ in leukemogenesis induced by MOZ/MLL fusion genes. As a result, I revealed that endogenous MOZ was essential for maintenance of active histone marks in target gene loci induced by MOZ/MLL fusion genes. Endogenous MOZ was also critical for suppression of INK4A tumor suppressor gene. These results suggest that endogenous MOZ was critical for leukemogenesis to maintain chrom

Research Products

• [Journal Article] 造血器腫瘍 転写制御 (2012)
  • Author(s): 勝本拓夫、北林一生
  • Journal Title: 日本臨床 Volume: 70 Pages: 75-78
• [Journal Article] 造血器腫瘍学―転写制御 (2012)
  • Author(s): 勝本 拓夫
  • Journal Title: 日本臨床 Volume: 70 Pages: 75-78
• [Journal Article] 転写共役因子を介した造血幹細胞と白血病幹細胞の制御機構 (2011)
  • Author(s): 勝本拓夫、北林一生
  • Journal Title: Mebio Volume: 28 Pages: 9-17
• [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. (2011)
  • Author(s): Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Takaho A. Endo, Tetsuro Toyoda, Jun Shinga, Takuo Katsumoto, Tetsuhiro Chiba, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama
  • Journal Title: Blood Volume: 118 Pages: 2443-53
  • Peer Reviewed
• [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis (2011)
  • Author(s): Mishima Y
  • Journal Title: Blood Volume: 118 Issue: 9 Pages: 2443-2453
  • DOI: 10.1182/blood-2011-01-331892
  • Peer Reviewed
• [Presentation] Roles of MOZ in leukemia development and HoxA9/Meis1 expression (2012)
  • Author(s): 勝本拓夫、山形和恒、北林一生
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌, 他
• [Presentation] Histone acetyltransferase MORF and MOZ are essential for hematopoiesis and self renewal of hematopoietic stem cells (2012)
  • Author(s): Takuo Katsumoto, Issay Kitabayashi
  • Organizer: 10^<th> ISSCR annual meeting
  • Place of Presentation: Yokohama, Japan
• [Presentation] MOZ is critical for MOZ/MLL-fusion-induced HoxA9/Meis1 expression and leukemia development (2012)
  • Author(s): 勝本拓夫、北林一生
  • Organizer: 第10回幹細胞シンポジウム
  • Place of Presentation: 淡路夢舞台
• [Presentation] Critical pathways for maintenance of stem cells in acute myeloid leukemia (2012)
  • Author(s): 嶋晴子、相川祐規子、篠美花、山形和恒、勝本拓夫、古関明彦、渡邊利雄、北林一生
  • Organizer: 第10回幹細胞シンポジウム
  • Place of Presentation: 淡路夢舞台
• [Presentation] ヒストンアセチル化酵素MOZの急性骨髄性白血病における役割 (2012)
  • Author(s): 勝本拓夫
  • Organizer: 平成23年度個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 琵琶湖ホテル
• [Presentation] Histone acetyltransferase MORF and MOZ are essential for hematopoiesis and self renewal of hematopoietic stem cells (2012)
  • Author(s): Takuo Katsumoto
  • Organizer: 10th ISSCR annual meeting
  • Place of Presentation: Pacifico Yokohama
• [Presentation] ヒストンアセチル化酵素MOZの急性骨髄性白血病における役割 (2012)
  • Author(s): 勝本 拓夫
  • Organizer: 「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 琵琶湖ホテル
• [Presentation] MOZ is critical for MOZ/MLL-fusion induced HoxA9/Meis1 expression and leukemia development (2011)
  • Author(s): Takuo Katsumoto, Issay Kiyabayashi
  • Organizer: 53^<rd> ASH annual meeting and exposition
  • Place of Presentation: San Diego, USA
• [Presentation] The critical role of YB-1 in NPMc-induced acute myeloid leukemia (2011)
  • Author(s): 小川原陽子、勝本拓夫、内海健、河野公俊、北林一生
  • Organizer: 第73回日本血液学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Histone acetyltransferase MOZ and MORF are essential for hematopoiesis and self renewal of hematopoietic stem cells (2011)
  • Author(s): 勝本拓夫、北林一生
  • Organizer: 第9回幹細胞シンポジウム
  • Place of Presentation: 泉ガーデンギャラリー
• [Presentation] MOZ is critical for MOZ/MLL-fusion-induced HoxA9/Meis1 expression and leukemia development (2011)
  • Author(s): Takuo katsumoto
  • Organizer: 53rd ASH annual meeting and exposition
  • Place of Presentation: San Diego Convention Center (USA)