The role of PI3Kgamma for the pathogenesis of asthma and potentiality for new therapeutic target of asthma

• Project/Area Number: 23791097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Akita University
• Principal Investigator: TAKEDA Masahide 秋田大学, 医学部, 助教 (30466594)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: PI3K / アレルギー / 喘息 / 好酸球 / eotaxin / PI3Kγ / PI3Kgamma / イノシトールリン脂質

Research Abstract

Eosinophils are involved in the pathogenesis of asthma. In this research, we investigated the role of PI3Kgamma for functions of human eosinophils using PI3Kgamma selective inhibitor. As a result, PI3Kgamma selective inhibitor suppressed eotaxin-induced eosinophil migration and activation. This study indicates that PI3Kgamma is involved in human eosinophil function and PI3Kgamma might be new therapeutic target of asthma and allergic diseases.

Research Products

• [Journal Article] Gender Difference in Allergic Airway Remodeling and Immunoglobulin Production In Mouse Model of Asthma. (2013)
  • Author(s): Takeda M
  • Journal Title: Respirology Volume: Mar 12 Issue: 5 Pages: 12078-12078
  • DOI: 10.1111/resp.12078
  • Peer Reviewed
• [Journal Article] Obesity and eosinophilic inflammation: does leptin play a role. (2012)
  • Author(s): Takeda M
  • Journal Title: Int Arch Allergy Immunol Volume: 158 suppl Issue: Suppl. 1 Pages: 87-91
  • DOI: 10.1159/000337799
  • Peer Reviewed
• [Journal Article] Docosahexaenoic acid exerts anti-inflammatory actions on human eosinophils through PPAR-independent mechanisms. (2012)
  • Author(s): Tanigai T
  • Journal Title: Int Arch Allergy Immunol. Volume: 158 Issue: 4 Pages: 375-386
  • DOI: 10.1159/000332965
  • Peer Reviewed
• [Journal Article] アレルギー性炎症における気道構成細胞とイノシトールリン脂質のかかわり (2011)
  • Author(s): 竹田正秀,茆原順一
  • Journal Title: 臨床免疫・アレルギー科 Volume: 56巻2号 Pages: 159-165
• [Journal Article] 病態 好酸球 (2011)
  • Author(s): 竹田正秀、茆原順一
  • Journal Title: 救急医学 Volume: 35巻5号 Pages: 536-540
• [Journal Article] 転写因子による制御 (2011)
  • Author(s): 竹田正秀、茆原真実、茆原順一
  • Journal Title: JOHNS Volume: 27巻11号 Pages: 1803-1808
• [Presentation] ヒト好酸球の接着能および活性酸素産生に対するPhosphoinositide 3-kinase γの関わり (2012)
  • Author(s): 齊藤由紀子、竹田正秀、植木重治、小林良樹、守時由起、糸賀正道、茆原真実、今野泰典、伊藤亘、茆原順一
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] The roles of Phosphoinositide 3-kinase gamma for eosinophil functions (2012)
  • Author(s): Takeda M, Saito Y, Ueki S, Konno Y, Chihara M, Itoga M, Moritoki Y, Kobayashi Y, Ito W, Chihara J.
  • Organizer: 31^th Congress of the European Academy of Allergology and Clinical Immunology
  • Place of Presentation: Geneva, Switzerland
• [Presentation] 好酸球の接着能・顆粒蛋白放出におけるPhosphoinositide 3-kinaseγの関わり (2012)
  • Author(s): 竹田正秀、伊藤亘、齊藤由紀子、植木重治、守時由起、小林良樹、糸賀正道、茆原真実、今野泰典、萱場広之、茆原順一
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] The roles of Phosphoinositide 3-kinase gamma for eosinophil functions. (2012)
  • Author(s): Takeda M
  • Organizer: 31th Congress of the European Academy of Allergology and Clinical Immunology
  • Place of Presentation: Geneva, Switzerland
• [Presentation] ヒト好酸球の接着能および活性酸素産生に対するPhosphoinositide 3-kinaseγの関わり (2012)
  • Author(s): 齊藤由紀子
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] ケモカインとgrowth factor産生測定によるマウス気道リモデリング形成の性差のメカニズムの検討 (2012)
  • Author(s): 竹田 正秀
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] ヒト好酸球機能におけるPhosphoinositide 3-kinase gammaの役割 (2011)
  • Author(s): 竹田正秀,伊藤亘,植木重治,今野泰典,茆原真実,糸賀正道,守時由起,小林良樹,萱場広之,茆原順一
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 好酸球細胞機能におけるPhosphoinositide 3-kinaseγの関わり (2011)
  • Author(s): 齊藤由紀子,竹田正秀,伊藤亘,木原純子,植木重治,小林良樹,守時由起,糸賀正道,今野泰典,茆原真実,萱場広之,茆原順一
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] ヒト好酸球の細胞生存および遊走能におけるPhosphoinositide 3-kinaseγの関わり (2011)
  • Author(s): 竹田正秀,伊藤亘,植木重治,木原純子,守時由起,谷貝朋美,糸賀正道,萱場広之,茆原順一
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
• [Presentation] ヒト好酸球機能におけるPhosphoinositide 3-kinase gammaの役割 (2011)
  • Author(s): 竹田正秀、伊藤亘、植木重治、今野泰典、茆原真実、糸賀正道、守時由起、小林良樹、萱場広之、茆原順一
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉