The role of PI3Kgamma for the pathogenesis of asthma and potentiality for new therapeutic target of asthma
Project/Area Number |
23791097
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Akita University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | PI3K / アレルギー / 喘息 / 好酸球 / eotaxin / PI3Kγ / PI3Kgamma / イノシトールリン脂質 |
Research Abstract |
Eosinophils are involved in the pathogenesis of asthma. In this research, we investigated the role of PI3Kgamma for functions of human eosinophils using PI3Kgamma selective inhibitor. As a result, PI3Kgamma selective inhibitor suppressed eotaxin-induced eosinophil migration and activation. This study indicates that PI3Kgamma is involved in human eosinophil function and PI3Kgamma might be new therapeutic target of asthma and allergic diseases.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] The roles of Phosphoinositide 3-kinase gamma for eosinophil functions2012
Author(s)
Takeda M, Saito Y, Ueki S, Konno Y, Chihara M, Itoga M, Moritoki Y, Kobayashi Y, Ito W, Chihara J.
Organizer
31^th Congress of the European Academy of Allergology and Clinical Immunology
Place of Presentation
Geneva, Switzerland
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[Presentation] 好酸球細胞機能におけるPhosphoinositide 3-kinaseγの関わり2011
Author(s)
齊藤由紀子,竹田正秀,伊藤亘,木原純子,植木重治,小林良樹,守時由起,糸賀正道,今野泰典,茆原真実,萱場広之,茆原順一
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Related Report
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