Studies on the mechanism of the tolerance break ofautoimmunity-Analysis of the T cells activation mechanism by epitope spreading-

Research Project

Project/Area Number	23791103
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	膠原病・アレルギー・感染症内科学
Research Institution	The University of Tokyo
Principal Investigator	SHIBUYA Mihoko 東京大学, 医学部附属病院, 助教 (20366363)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	膠原病学 / エピトープスプレディング / 免疫学 / 自己反応性T細胞 / 抗原特異性
Research Abstract	We have investigated ‘Extended antigen presentation (EAP)’, a new mechanism of naive T cell activation, using two pairs of cognate antigens and antigen-specific T cells, TEa and OT-II. In this project, we used third antigen-specific T cells; 2D2. With three Tcells model, we proved antigen dependency and universality of EAP.

Report

(3 results)