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Studies on the mechanism of the tolerance break ofautoimmunity-Analysis of the T cells activation mechanism by epitope spreading-

Research Project

Project/Area Number 23791103
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

SHIBUYA Mihoko  東京大学, 医学部附属病院, 助教 (20366363)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膠原病学 / エピトープスプレディング / 免疫学 / 自己反応性T細胞 / 抗原特異性
Research Abstract

We have investigated ‘Extended antigen presentation (EAP)’, a new mechanism of naive T cell activation, using two pairs of cognate antigens and antigen-specific T cells, TEa and OT-II. In this project, we used third antigen-specific T cells; 2D2. With three Tcells model, we proved antigen dependency and universality of EAP.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2012 2011

All Presentation (4 results)

  • [Presentation] Without cognate antigens T cell proliferation induced by 'Extended antigen presentation' was not observed2012

    • Author(s)
      Mihoko Shibuya
    • Organizer
      第8回国際自己免疫疾患学会議
    • Place of Presentation
      Palaciode Exposiciones y Congresos de Granada、スペイン
    • Year and Date
      2012-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] WITHOUT COGNATE ANTIGENS T CELL PROLIFERATION INDUCED BY ‘EXTENDED ANTIGEN PRESENTATION’ WAS NOT OBSERVED.2012

    • Author(s)
      澁谷美穂子
    • Organizer
      第8回国際自己免疫疾患学会議
    • Place of Presentation
      Palacio de Exposiciones y Congresos de Granada、スペイン
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特異抗原が存在しないと拡張抗原によるT細胞の活性化は起こらない2011

    • Author(s)
      澁谷美穂子
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 特異抗原が存在しないと拡張抗原によるT細胞の活性化は起こらない2011

    • Author(s)
      澁谷美穂子
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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