Research Project
Grant-in-Aid for Young Scientists (B)
We could not prove the hypothesis that microbiota could induce regulatory T cells and suppress allergic airway inflammation. Transcription factor Blimp-1 is thought to be implicated in the regulatory function of LAG3+Tregs, which is recently proposed as a novel regulatory T cell subcet. We showed that Blimp-1 expression of T cells enhanced eosiophil infiltration and suppressed lymphocyte infiltration and collagen deposition in mice with allergic airway inflammation. Our study indicates that LA3+Tregs are involved in the pathogenesis of allergic airway inflammation.
