Abrogation of CCR9 ameliorates murine collagen-induced arthritis

• Project/Area Number: 23791110
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: WATANABE Kaori 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座助教 (30581582)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: CCR9 / CCL25 / ケモカイン / 関節炎 / 関節リウマチ

Research Abstract

Stimulation with CCL25 enhanced production of inflammatoy mediators from synoviocytes or monocytes and also enhanced osteoclastogenesis. Blocking of CCR9 inhibited murine collagen-induced arthritis. CCR9 antagonist reduced migration of macrophages into the synovial tissue of the mice with arthritis.