| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
A therapy that inhibits only autoreactive lymphocytes is desirable for the treatment of systemic lupus erythematosus (SLE). We analyzed an SLE model ‘anti-DNA-antibody-knock-in mouse' to know how autoreactive B cells are regulated. The homozygotes' splenic B cells were significantly decreased, and their maturation was inhibited in the bone marrow. Homo's B cells tended to move to the marginal zone in their spleens. Homo's B cells showed low expression levels of IgM/IgD, and were supposed to be regulated by anergy. Further analyses will elucidate the pathophysiology of SLE.
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