| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The new autoantibodies were screened by the AlphaScreen methodusing sera from eight antiCCP antibody-negative rheumatoid factor-negative rheumatoid arthritis (RA) patients. In two candidate proteins which were detected in all sera by AlphaScreen method, the autoantibodies were determined by Western blot and ELISA. Although autoantibodies were detected by Western blot, the detection rate was low by ELISA. These antibodies may become the new autoantibody in the autoantibody-negative RA. Next, we are going to examine the clinical utility of these autoantibodies.
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