| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To study the role of GM-CSF secreting CD4 T cells in rheumatoid arthritis, we conducted co-culture experiments of human lymphocytes and animal experiments. By co-culture experiments, we identified a molecule expressed on fibroblast-like synoviocyte (FLS) which drives the production of GM-CSF from naive CD4 T cells. By animal experiments, we found that GM-CSF produced by CD4 T cells at the site of inflammation promoted inflammation by enhancing the production of IL-6, IL-1 and TNF from macrophages.
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