Role of GM-CSF secreting CD4 T cells in rheumatoid arthritis and its animal model
Project/Area Number |
23791113
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 関節リウマチ / CD4T 細胞 / GM-CSF / fibroblast-like synoviocyte / CD4T細胞 |
Research Abstract |
To study the role of GM-CSF secreting CD4 T cells in rheumatoid arthritis, we conducted co-culture experiments of human lymphocytes and animal experiments. By co-culture experiments, we identified a molecule expressed on fibroblast-like synoviocyte (FLS) which drives the production of GM-CSF from naive CD4 T cells. By animal experiments, we found that GM-CSF produced by CD4 T cells at the site of inflammation promoted inflammation by enhancing the production of IL-6, IL-1 and TNF from macrophages.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database2013
Author(s)
Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
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Journal Title
PLoS One
Volume: 8(3)
Issue: 3
Pages: e59341-e59341
DOI
NAID
Related Report
Peer Reviewed
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