| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
In the autoimmune disease, auto-reactive B cells are activated and produce theautoantibodies, which induce the tissue injury. We found that abnormal expression of G5PR,one of the B’’ regulatory subunit of the serine/threonine protein phosphatase 2A,induced the expansion of B-1a cells in the peritoneal cavity and generation ofautoantibodies in mice. Over-expression of G5PR in B-1a cells suppressed the JNK-mediatedapoptotic signal pathway and rescued from activation-induced cell death by antigenstimulation. These results suggest that G5PR may play a pivotal role in B cell selectionfor B-1a cells and in the development of autoimmune disease.
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